I feel good but have high estradiol- Should I treat?

[Warrior]

Long time TRT user, never had any sides etc. Yearly bloodwork was just done, estradiol was 67. Total T was 567 in trough. Free 155. Looking back, estradiol is always 64 to 67 which I know is higher? Dont have any problems just looking for feedback please.

 

[Systemlord]

Total T was 567 in trough. Free 155.

Do you have ranges for those Free T values?

Looking back, estradiol is always 64 to 67 which I know is higher?

My estrogen is high on TRT, no problems either.

Dont have any problems just looking for feedback please.

If you don't have any problems and you feel optimal, then no need to change anything.

 

[Vince]

I agree with Systemlord, no sides. No issues.

 

[Cataceous]

Don't be lulled by the fallacy that something is safe just because it's not currently causing any problems. A lot of smokers feel fine right up until they develop lung cancer. This isn't to imply that there is comparable long-term risk in having both estradiol and the estradiol/testosterone ratio sitting many standard deviations above normal. The problem is we don't know what the risk is. We also don't know if it's any safer to force levels down to normal with an aromatase inhibitor.

I know this is unsatisfying, but in your shoes I'd still prefer to be aware of what I don't know. I see that your hCG dose is already pretty low, removing some low-hanging fruit with respect to improving your numbers.

 

[Warrior]

Don't be lulled by the fallacy that something is safe just because it's not currently causing any problems. A lot of smokers feel fine right up until they develop lung cancer. This isn't to imply that there is comparable long-term risk in having both estradiol and the estradiol/testosterone ratio sitting many standard deviations above normal. The problem is we don't know what the risk is. We also don't know if it's any safer to force levels down to normal with an aromatase inhibitor.

I know this is unsatisfying, but in your shoes I'd still prefer to be aware of what I don't know. I see that your hCG dose is already pretty low, removing some low-hanging fruit with respect to improving your numbers.

I didnt report my HCG numbers? But I do standard 250iu 2x per week.

 

[Nelson Vergel]

estradiol was 67

Sensitive LC/MS test assay?

 

[Nelson Vergel]

Read this: Effect of Estradiol on Men's Libido

 

[Jed Dorsey]

Don't be lulled by the fallacy that something is safe just because it's not currently causing any problems. A lot of smokers feel fine right up until they develop lung cancer. This isn't to imply that there is comparable long-term risk in having both estradiol and the estradiol/testosterone ratio sitting many standard deviations above normal. The problem is we don't know what the risk is. We also don't know if it's any safer to force levels down to normal with an aromatase inhibitor.

I know this is unsatisfying, but in your shoes I'd still prefer to be aware of what I don't know. I see that your hCG dose is already pretty low, removing some low-hanging fruit with respect to improving your numbers.

Cataceous is absolutely right in saying we just don’t know what the risks are. Just because we feel good doesn’t necessarily mean everything is all good. Why not err in the side caution and stay within range.

 

[Nelson Vergel]

I would not start an AI if you feel fine. Did you get estradiol measured by LC/MS or ECLIA?

 

[Jed Dorsey]

Nelson I know that your not in favor of AI but I must take you to task on this. If he feels good takes an LC/MS or ECLIA test and is still high what then?

 

[Nelson Vergel]

Nelson I know that your not in favor of AI but I must take you to task on this. If he feels good takes an LC/MS or ECLIA test and is still high what then?

I would then ask him what his hematocrit and his HDL are. Obviously, he seems to feel good (including good libido).

Higher estradiol was correlated to higher libido in this NIH funded study done by the top researcher in the field (DR Bhasin, the same guy that did a study giving men 600 mg/week of testosterone):

Higher Estradiol, T and DHT correlated to higher libido in older hypogonadal men than T alone

Relation of Testosterone, Dihydrotestosterone, and Estradiol with Changes in Outcomes Measures in the Testosterone Trials (2022) Alisa J. Stephens-Shields, PhD, Peter J. Snyder, MD, Susan S. Ellenberg, PhD, Lynne Taylor, PhD, Shalender Bhasin, MB, BS Abstract Context. Many effects of...

www.excelmale.com

MECHANISMS IN ENDOCRINOLOGY: Estradiol as a male hormone​

High Estradiol Boosts Libido in Men on Testosterone Therapy

I have been warning men and clinics not to be so aggressive treating estradiol in men with the overuse of anastrozole. Here is a recent study done in Houston. Elevated serum estradiol is associated with increased libido in men receiving testosterone replacement therapy (TRT), according to...

www.excelmale.com

Another benefit of estradiol in men:

Testosterone Needs to Be Converted into Estradiol to Prevent Fat Accumulation

How Targeting Fat Cells’ Estrogen Receptors Could Fight Obesity Tracy Hampton, PhD In adipocytes, fat cells, a particular estrogen-receptor appears critical for energy supplying mitochondria to function properly. The discovery points to a potential drug target for boosting fat tissue...

www.excelmale.com

 

[Jed Dorsey]

These are all good points and who wouldn’t want good erections however it’s still well known in the medical community elevated serum estradiol is associated with increased cases of breast cancer. Maybe it’s just me but I prefer to do a half milligram AI weekly and keeps me in range and libido is still awesome to the point my wife is getting annoyed LOL

 

[JmarkH]

So, Warrior, you said, "I feel good but have high estradiol- Should I treat?"
I say why not. Treat yourself to a Hallmark movie and a good cry. Or, have sex with the wife and cuddle.

 

[Systemlord]

it’s still well known in the medical community elevated serum estradiol is associated with increased cases of breast cancer.

Inflammation and increased body fat is was contributes to increased risk of breast cancer.

Increases in body fat creates more aromatase and therefore higher estrogen.

The estrogen is the smoke, not the fire.

 

[Nelson Vergel]

it’s still well known in the medical community elevated serum estradiol is associated with increased cases of breast cancer.

This is debatable. This was a conclusion of the WHI study which has been debunked several times. Read this book, it's amazingly well written:

"For years, hormone replacement therapy (HRT) was hailed as a miracle. Study after study showed that HRT, if initiated at the onset of menopause, could ease symptoms ranging from hot flashes to memory loss; reduce the risk of heart disease, Alzheimer's, osteoporosis, and some cancers; and even extend a woman's overall life expectancy. But when a large study by the Women's Health Initiative announced results showing an uptick in breast cancer among women taking HRT, the winds shifted abruptly, and HRT, officially deemed a carcinogen, was abandoned.

Now, sixteen years after HRT was left for dead, Dr. Bluming, a medical oncologist, and Dr. Tavris, a social psychologist, track its strange history and present a compelling case for its resurrection. They investigate what led the public -- and much of the medical establishment -- to accept the Women's Health Initiative's often exaggerated claims, while also providing a fuller picture of the science that supports HRT.

A sobering and revelatory read, Estrogen Matters sets the record straight on this beneficial treatment and provides an empowering path to wellness for women everywhere."

https://www.amazon.com/Estrogen-Matters-Hormones-Menopause-Well-Being/

 

[Jed Dorsey]

This is debatable. This was a conclusion of the WHI study which has been debunked several times. Read this book, it's amazingly well written:

"For years, hormone replacement therapy (HRT) was hailed as a miracle. Study after study showed that HRT, if initiated at the onset of menopause, could ease symptoms ranging from hot flashes to memory loss; reduce the risk of heart disease, Alzheimer's, osteoporosis, and some cancers; and even extend a woman's overall life expectancy. But when a large study by the Women's Health Initiative announced results showing an uptick in breast cancer among women taking HRT, the winds shifted abruptly, and HRT, officially deemed a carcinogen, was abandoned.

Now, sixteen years after HRT was left for dead, Dr. Bluming, a medical oncologist, and Dr. Tavris, a social psychologist, track its strange history and present a compelling case for its resurrection. They investigate what led the public -- and much of the medical establishment -- to accept the Women's Health Initiative's often exaggerated claims, while also providing a fuller picture of the science that supports HRT.

A sobering and revelatory read, Estrogen Matters sets the record straight on this beneficial treatment and provides an empowering path to wellness for women everywhere."

https://www.amazon.com/Estrogen-Matters-Hormones-Menopause-Well-Being/

Thanks but the link didn’t work for me. Please verify

 

[tareload]

Thanks but the link didn’t work for me. Please verify

Estrogen Matters: Why Taking Hormones in Menopause Can Improve Women's Well-Being and Lengthen Their Lives -- Without Raising the Risk of Breast Cancer
Amazon.com

 

[Nelson Vergel]

Estrogen Matters: Why Taking Hormones in Menopause Can Improve Women's Well-Being and Lengthen Their Lives -- Without Raising the Risk of Breast Cancer
Amazon.com