High estradiol and SHBG 10wks into TRT (was high on enclomiphene too) - long winded post sorry.

Sandz

New Member
I was brought here after listening to Nelson on Dr. Lyons podcast, man what a story and journey!

48M, 5'6" 160lbs.

I lost 90lbs 25 years ago and have kept in shape ever since. I workout daily, love being in the gym, but never truly felt optimized. This last year or two I made it a goal to feel comfortable in my own skin and get into the best shape by 50, so I felt it was valuable to go check more labs than a typical provider did.

In the end, I tested with low free T multiple times, always under 4.0. My Total T was 350-450ish throughout my 40s. Wasnt educated enough to test other markers, but I am really trying to tune into my body these days.

I got on an enclomiphene, and came to realize less is more. I was on 12.5mg, but ended up dialing down to 6.25EOD. I never felt great, eye flutters, and I didn't see the benefit, so I stopped after terrible Gerd (perhaps not related but I think it was).

Total T on elnclo was btwn 900 and then 1000.
Free T was consistently hovering around 14
SHBG was consistently high at 63 then 50 - (50 even before starting anything)
Estradiol btwn 38-40 from btwn 8-15 without any treatments

Started TRT - subq 2x a week - .3cc so 120mgs a week about 10wks ago. Feeling better than elcno, biggest change so far is irritability and attitude. Less agitated, more focused day to day. Workouts a little better, feeling a touch stronger, slight.
Total T - over 1500
Free T - 17.3
SHBG - 67
Estradiol 60
Sensitive estradiol 53
DHEA 157 taking 25mg a day

So, bottom line, I don't need my T to be over 1500.
I an lowering my dose to 100mg a week, .25cc 2x a week subQ
Adding in Nettle root, extract and root 300mg/150mg
Adding in 3mg or 6mg Boron
Adding in calcium d-glucarate 500mg
Continuing to take Dim 300mg which I started with TRT

I want to take advantage of the T, so bound testosterone doesn't seem valuable. I am not terribly afraid of the E2, I don't feel gyno but I do feel like my sleep isn't good, and I am retaining water which is expected on T, its mild (1-2lb). Doc suggested small dose of AI, but I don't think I need to jump there just yet unless my case is cause for it. Also in the fall, I had a terrible bout with Gerd and I believe its from the T and E being elevated. I hope lowering my dose and adding in support naturally is the winner, but I don't often see people with both High E2 and SHBG although I am sure its been documented I just cant find a lot of scenarios like mine. I want to take the maximum benefit, I dont need to be at a certain number, if it lands at 800, so be it. I just want to get my E2 and SHBG in check.

Any other questions or advise, please let me know. Any input is appreciated. Ill keep searching the forum too, its a fantastic resource!
 

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