How long does it take for estradiol to go up after stopping anastrozole?

[Greg Kevorkian]

After stopping anastrazole. how long before E2 goes up?

 

[Vince]

Arimidex has a 50 hour half life. A drug is considered to have cleared your system after five half-lives.

 

[Systemlord]

Your estrogen will increase long before you realizes it, there is a lag time until your body will start to feel it which makes dosing anastrozole even more difficult.

I was unfortunate enough to experience the horrible E2 rebound affect, it felt like a front row seat to what a heart attack must feel like which forced me to give up on AI's entirely. The only way out for me was either taking more anastrozole trapped in an endless vicious cycle or stop TRT for a time to where there is less aromatization.

 

[Nelson Vergel]

Guys, please search your question in the search box.

How long does it take estradiol to come back after a crash

 

[Greg Kevorkian]

Your estrogen will increase long before you realizes it, there is a lag time until your body will start to feel it which makes dosing anastrozole even more difficult.

I was unfortunate enough to experience the horrible E2 rebound affect, it felt like a front row seat to what a heart attack must feel like which forced me to give up on AI's entirely. The only way out for me was either taking more anastrozole trapped in an endless vicious cycle or stop TRT for a time to where there is less aromatization.

 

[Greg Kevorkian]

Go on YouTube and check out jay Campbell on AI also his interview with dr Keith Nichols and dr Neil rouzier. Extremely interesting !

 

[Greg Kevorkian]

Arimidex has a 50 hour half life. A drug is considered to have cleared your system after five half-lives.

I would assume the effectiveness of the drug would be reduced earlier than 5 half lives?

 

[Greg Kevorkian]

Basically I’m suggesting that E2 would come back earlier than 5 half lives. What say you ?
And thanks foR the posts!!

 

[Cataceous]

Basically I’m suggesting that E2 would come back earlier than 5 half lives. What say you ?
...

Depends how you define "come back". The "5 half-lives" figure just means that in theory most of the drug has been cleared by then. Because anastrozole works by competitive inhibition, as soon as concentrations start dropping more aromatase is freed up to start forming estradiol. So estradiol will start going up fairly quickly. But getting back to baseline could actually take the 5+ half-lives unless there's a surplus of aromatase. There's speculation that more aromatase is made in reaction to the inhibition, but there's no solid evidence for it as far as I know.

 

[Greg Kevorkian]

Interesting thank you

 

[Joe Sixpack]

I was unfortunate enough to experience the horrible E2 rebound affect, it felt like a front row seat to what a heart attack must feel like

What were your symptoms? And these symptoms were due to the elevated rebound E2?

 

[Systemlord]

What were your symptoms?

My heart had never raced that quickly even while coming off benzos after 30 years, no comparison.

And these symptoms were due to the elevated rebound E2?

Yes they were, it's why I chucked the AI for good. I actually tapped out and took the AI again, then stopped TRT for a week so the E2 rebound couldn't occur again in a week.

I actually believe my left ventricular dysfunction diagnosis is the result of the 10 month benzo withdrawal.

 

[Joe Sixpack]

My heart had never raced that quickly even while coming off benzos after 30 years, no comparison.

Yes they were, it's why I chucked the AI for good. I actually tapped out and took the AI again, then stopped TRT for a week so the E2 rebound couldn't occur again in a week.

I actually believe my left ventricular dysfunction diagnosis is the result of the 10 month benzo withdrawal.

Sounds horrible indeed