When to take Anastrozole

notthesameguy

New Member
Hey Guys

I have had high E2 through my TRT duration (5 years) and have had difficulty managing. I also have high SHBG. Latest BT =
Estradiol- 59
SHBG - 127
T -1200-1500

I went off anastrozole for 6 months but starting back. My typical protocol is :
55 mg test cyp 2x/week
HCG 2x/week
I have script for Anastrozole .125 3x/week

my question is when is optimal day/time to take AI if my inject days are Wed a.m. and Saturday p.m. ?

thanks for any suggestions.

NTSG
 
Hey Guys

I have had high E2 through my TRT duration (5 years) and have had difficulty managing. I also have high SHBG. Latest BT =
Estradiol- 59
SHBG - 127
T -1200-1500

I went off anastrozole for 6 months but starting back. My typical protocol is :
55 mg test cyp 2x/week
HCG 2x/week
I have script for Anastrozole .125 3x/week

my question is when is optimal day/time to take AI if my inject days are Wed a.m. and Saturday p.m. ?

thanks for any suggestions.

NTSG
I believe it's 24 hours after injection but any time during the week should work. Why are you considering using an AI?
 
Well my free T was not in the range desired. So increased testosterone to raise the free, which in turn results in high E2. Very noticeable effects of high E2 on libido and erectile function.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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