High Iron, Low Ferritin (high-normal cbc)

[thedeparted]

So I have a call into Defy after my General Practitioner running labs for my annual physical, but they are closed for the weekend so I was just seeing what you all think of these #'s for now.

I have been doing regular blood donations (3 since last October.) I am currently 3 months on a high dose HCG mono for infertility/low test. And prior to that was 6 months on a low dose Clomid protocol.

Obviously I need to get the iron out of my system, but with the low ferritin my GP Dr doesn't recommend another blood donation. I'm assuming I should back off of the HCG until I can get my Iron back in check?




Component Results

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]WBC[/TD] [TD="class: valueCol"]6.1 K/uL[/TD] [TD="class: rangeCol"]4.0 - 10.7 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]RBC[/TD] [TD="class: valueCol"]5.58 10*6[/TD] [TD="class: rangeCol"]4.20 - 5.60 10*6[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]HEMOGLOBIN[/TD] [TD="class: valueCol"]17.2 GM/DL[/TD] [TD="class: rangeCol"]13.2 - 17.4 GM/DL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]HEMATOCRIT[/TD] [TD="class: valueCol"]49 %[/TD] [TD="class: rangeCol"]38 - 50 %[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCV[/TD] [TD="class: valueCol"]87[/TD] [TD="class: rangeCol"]80 - 98[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCH[/TD] [TD="class: valueCol"]31[/TD] [TD="class: rangeCol"]27 - 34[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCHC[/TD] [TD="class: valueCol"]35 %[/TD] [TD="class: rangeCol"]33 - 37 %[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]RDW[/TD] [TD="class: valueCol"]12.7[/TD] [TD="class: rangeCol"]8.0 - 18.5[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]PLATELET COUNT[/TD] [TD="class: valueCol"]213 10*3[/TD] [TD="class: rangeCol"]140 - 450 10*3[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]Neutrophils, Absolute[/TD] [TD="class: valueCol"]3.30 K/uL[/TD] [TD="class: rangeCol"]2.00 - 7.30 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]Lymphocytes, Absolute[/TD] [TD="class: valueCol"]1.90 K/uL[/TD] [TD="class: rangeCol"]1.00 - 3.40 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MONOCYTES, ABSOLUTE[/TD] [TD="class: valueCol"]0.60 K/uL[/TD] [TD="class: rangeCol"]0.00 - 0.80 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]Eosinophils, Absolute[/TD] [TD="class: valueCol"]0.20 K/ul[/TD] [TD="class: rangeCol"]0.0 - 0.5 K/ul[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]Basophils, Absolute[/TD] [TD="class: valueCol"]0.10 K/uL[/TD] [TD="class: rangeCol"]0.0 - 0.2 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]COMMENT[/TD] [TD="class: valueCol"]Automated differential[/TD] [TD="class: rangeCol"][/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]FERRITIN[/TD] [TD="class: valueCol"]15 ng/mL[/TD] [TD="class: rangeCol"]30 - 400 ng/mL[/TD] [TD="class: flagCol"]L[/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]IRON[/TD] [TD="class: valueCol"]211 ug/dL[/TD] [TD="class: rangeCol"]52 - 150 ug/dL[/TD] [TD="class: flagCol"]H[/TD]

[TD="class: nameCol srchbl"]TIBC[/TD] [TD="class: valueCol"]392 ug/dL[/TD] [TD="class: rangeCol"]240 - 400 ug/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]% SATURATION[/TD] [TD="class: valueCol"]54 %[/TD] [TD="class: rangeCol"]15 - 50 %[/TD] [TD="class: flagCol"]H[/TD]

 

[johndoesmith]

You're going to need to post the rest of the labs.

Chances are you have something else going on that is causing the erythropoiesis. Sleep apnea is most likely. Or testosterone is super high.

3 donations in under 1 year is a lot. Your ferritin is tanked, donating blood at this point is a bandaid solution, you need to get to the cause of this and treat that.

 

[thedeparted]

Sleep apnea test showed snoring, but no spnea. Polycythemia and Polycythemia vera tests came back negative. Dr. is running a hereditary hemochromotosis test that hasn't came back yet.

Even prior to starting clomid/hcg my cbc was high normal.

Here are some more labs, I have many more so if you don't see something specific I may have just not posted it.

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]JAK2 MUTATION[/TD] [TD="class: valueCol"]NEGATIVE pg/uL[/TD] [TD="class: rangeCol"]pg/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]JAK2 MUTATION INTERPRETATION[/TD] [TD="class: valueCol"]SEE NOTE [/TD] [TD="class: rangeCol"]NEGATIVE[/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]ERYTHROPOETIN[/TD] [TD="class: valueCol"]11 mU/mL[/TD] [TD="class: rangeCol"]4 - 27 mU/mL[/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]DHEA-SULFATE (ADULT)[/TD] [TD="class: valueCol"]387 mcg/dL[/TD] [TD="class: rangeCol"]160 - 449 mcg/dL[/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]CHOLESTEROL[/TD] [TD="class: valueCol"]158 mg/dL[/TD] [TD="class: rangeCol"]100 - 199 mg/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]HDL CHOLESTEROL[/TD] [TD="class: valueCol"]42 mg/dL[/TD] [TD="class: rangeCol"]40 - 120 mg/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]CHOL/HDL RATIO[/TD] [TD="class: valueCol"]3.8 RATIO[/TD] [TD="class: rangeCol"]1.5 - 5.0 RATIO[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]TRIGLYCERIDES[/TD] [TD="class: valueCol"]86 mg/dL[/TD] [TD="class: rangeCol"]40 - 249 mg/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]LDL CHOLESTEROL[/TD] [TD="class: valueCol"]99 mg/dL[/TD] [TD="class: rangeCol"]30 - 99 mg/dL[/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]SODIUM[/TD] [TD="class: valueCol"]140 MEQ/L[/TD] [TD="class: rangeCol"]135 - 145 MEQ/L[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]POTASSIUM[/TD] [TD="class: valueCol"]4.3 MEQ/L[/TD] [TD="class: rangeCol"]3.5 - 5.2 MEQ/L[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]CHLORIDE[/TD] [TD="class: valueCol"]104 MEQ/L[/TD] [TD="class: rangeCol"]99 - 108 MEQ/L[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]CARBON DIOXIDE[/TD] [TD="class: valueCol"]28 MEQ/L[/TD] [TD="class: rangeCol"]22 - 32 MEQ/L[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]GLUCOSE[/TD] [TD="class: valueCol"]87 mg/dL[/TD] [TD="class: rangeCol"]65 - 140 mg/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: srchbl, colspan: 4"]GLUCOSE REFERENCE RANGES: Fasting glucose 65 - 99 mg/dL Random glucose 70 - 126 mg/dL 2 hour post prandial 70 - 140 mg/dL[/TD]

[TD="class: nameCol srchbl"]BUN[/TD] [TD="class: valueCol"]13 mg/dL[/TD] [TD="class: rangeCol"]6 - 24 mg/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]CREATININE[/TD] [TD="class: valueCol"]1.10 mg/dL[/TD] [TD="class: rangeCol"]0.50 - 1.40 mg/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]CALCIUM[/TD] [TD="class: valueCol"]9.9 mg/dL[/TD] [TD="class: rangeCol"]8.6 - 10.3 mg/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]TOTAL PROTEIN[/TD] [TD="class: valueCol"]7.1 G/DL[/TD] [TD="class: rangeCol"]5.8 - 8.0 G/DL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]ALBUMIN[/TD] [TD="class: valueCol"]4.8 G/DL[/TD] [TD="class: rangeCol"]3.4 - 5.2 G/DL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]BILIRUBIN,TOTAL[/TD] [TD="class: valueCol"]1.1 mg/dL[/TD] [TD="class: rangeCol"]0.2 - 1.1 mg/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]AST[/TD] [TD="class: valueCol"]30 U/L[/TD] [TD="class: rangeCol"]6 - 35 U/L[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]ALK PHOS[/TD] [TD="class: valueCol"]66 U/L[/TD] [TD="class: rangeCol"]30 - 125 U/L[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]ALT[/TD] [TD="class: valueCol"]26 U/L[/TD] [TD="class: rangeCol"]5 - 50 U/L[/TD] [TD="class: flagCol"][/TD]

[TD="class: srchbl, colspan: 4"]Patients taking sulfasalazine may have falsely low ALT results.[/TD]

[TD="class: nameCol srchbl"]GFR -- AFRICAN AMERICAN[/TD] [TD="class: valueCol"]above 60 ML/MIN[/TD] [TD="class: rangeCol"]60 - 100 ML/MIN[/TD] [TD="class: flagCol"][/TD]

[TD="class: srchbl, colspan: 4"]If you are African American, no significant chronic kidney disease found.[/TD]

[TD="class: nameCol srchbl"]GFR -- NON-AFRICAN AMERICAN[/TD] [TD="class: valueCol"]above 60 ML/MIN[/TD] [TD="class: rangeCol"]60 - 100 ML/MIN[/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]SEX HORMONE BIND PROTEIN-SHBG[/TD] [TD="class: valueCol"]25 nmol/L[/TD] [TD="class: rangeCol"]10 - 50 nmol/L[/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]ESTRADIOL (ADULT)[/TD] [TD="class: valueCol"]43 pg/mL[/TD] [TD="class: rangeCol"]8 - 43 pg/mL[/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]TOTAL TESTOSTERONE[/TD] [TD="class: valueCol"]637 ng/dL[/TD] [TD="class: rangeCol"]250 - 1100 ng/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]FREE TESTOSTERONE[/TD] [TD="class: valueCol"]116.9 pg/mL[/TD] [TD="class: rangeCol"]35.0 - 155.0 pg/mL[/TD]

 

[johndoesmith]

Sleep apnea test showed snoring, but no spnea. Polycythemia and Polycythemia vera tests came back negative. Dr. is running a hereditary hemochromotosis test that hasn't came back yet.

Even prior to starting clomid/hcg my cbc was high normal.

Here are some more labs, I have many more so if you don't see something specific I may have just not posted it.

Something else is causing this then. You said it was high normal prior to clomid and hCG.

I'd suspect you do have sleep apnea, if you have the sleep study results I'd suggest a second opinion. If you don't, request them.

Either that or you live at altitude or smoke cigarettes.

 

[thedeparted]

Something else is causing this then. You said it was high normal prior to clomid and hCG.

I'd suspect you do have sleep apnea, if you have the sleep study results I'd suggest a second opinion. If you don't, request them.

Either that or you live at altitude or smoke cigarettes.

It was just one of those take home tests that you wear for a night, not a full sleep study. Maybe Ill push them for a full study.

Also never a smoker, and only live at 300 ft altitude.

This is my pre-clomid, pre-hcg cbc from August of last year:

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]WBC[/TD] [TD="class: valueCol"]5.3 K/uL[/TD] [TD="class: rangeCol"]4.0 - 10.7 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]RBC[/TD] [TD="class: valueCol"]5.78 10*6[/TD] [TD="class: rangeCol"]4.20 - 5.60 10*6[/TD] [TD="class: flagCol"]H[/TD]

[TD="class: nameCol srchbl"]HEMOGLOBIN[/TD] [TD="class: valueCol"]18.0 GM/DL[/TD] [TD="class: rangeCol"]13.2 - 17.4 GM/DL[/TD] [TD="class: flagCol"]H[/TD]

[TD="class: nameCol srchbl"]HEMATOCRIT[/TD] [TD="class: valueCol"]53 %[/TD] [TD="class: rangeCol"]38 - 50 %[/TD] [TD="class: flagCol"]H[/TD]

[TD="class: nameCol srchbl"]MCV[/TD] [TD="class: valueCol"]91 [/TD] [TD="class: rangeCol"]80 - 98[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCH[/TD] [TD="class: valueCol"]31 [/TD] [TD="class: rangeCol"]27 - 34[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCHC[/TD] [TD="class: valueCol"]34 %[/TD] [TD="class: rangeCol"]33 - 37 %[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]RDW[/TD] [TD="class: valueCol"]13.1 [/TD] [TD="class: rangeCol"]8.0 - 18.5[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]PLATELET COUNT[/TD] [TD="class: valueCol"]216 10*3[/TD] [TD="class: rangeCol"]140 - 450 10*3[/TD]

 

[johndoesmith]

It was just one of those take home tests that you wear for a night, not a full sleep study. Maybe Ill push them for a full study.

Also never a smoker, and only live at 300 ft altitude.

This is my pre-clomid, pre-hcg cbc from August of last year:

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]WBC[/TD] [TD="class: valueCol"]5.3 K/uL[/TD] [TD="class: rangeCol"]4.0 - 10.7 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]RBC[/TD] [TD="class: valueCol"]5.78 10*6[/TD] [TD="class: rangeCol"]4.20 - 5.60 10*6[/TD] [TD="class: flagCol"]H[/TD]

[TD="class: nameCol srchbl"]HEMOGLOBIN[/TD] [TD="class: valueCol"]18.0 GM/DL[/TD] [TD="class: rangeCol"]13.2 - 17.4 GM/DL[/TD] [TD="class: flagCol"]H[/TD]

[TD="class: nameCol srchbl"]HEMATOCRIT[/TD] [TD="class: valueCol"]53 %[/TD] [TD="class: rangeCol"]38 - 50 %[/TD] [TD="class: flagCol"]H[/TD]

[TD="class: nameCol srchbl"]MCV[/TD] [TD="class: valueCol"]91[/TD] [TD="class: rangeCol"]80 - 98[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCH[/TD] [TD="class: valueCol"]31[/TD] [TD="class: rangeCol"]27 - 34[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCHC[/TD] [TD="class: valueCol"]34 %[/TD] [TD="class: rangeCol"]33 - 37 %[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]RDW[/TD] [TD="class: valueCol"]13.1[/TD] [TD="class: rangeCol"]8.0 - 18.5[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]PLATELET COUNT[/TD] [TD="class: valueCol"]216 10*3[/TD] [TD="class: rangeCol"]140 - 450 10*3[/TD]

You should definitely get a full sleep study performed.

 

[thedeparted]

Just searching around I wonder if it could be Primary familial and congenital polycythemia (PFCP)
https://www.ncbi.nlm.nih.gov/books/NBK395975/

[FONT=&quot]Laboratory findings[/FONT]

• Complete blood count that shows isolated absolute erythrocytosis:
  
  • Normal platelet and white cell counts, which demonstrate non-involvement of other hematopoietic cell lines and confirm isolated erythrocytosis
    
  • Hemoglobin and hematocrit in at least two separate blood counts performed at different times that are above the normal reference range (adjusted to age and sex) and confirm absolute erythrocytosis
    Note: Absolute erythrocytosis is distinct from: (1) relative erythrocytosis, caused by severe reduction in plasma volume (e.g., due to diuretics or severe diarrhea) and (2) apparent erythrocytosis, caused by arterial hypoxemia (e.g., cigarette smoking, carbon monoxide poisoning, or sleep apnea) (reviewed in McMullin et al [2005]).
• Normal hemoglobin oxygen affinity measured as P50 (i.e., the partial pressure of oxygen in the blood at which hemoglobin is 50% saturated)
• Erythropoietin (EPO) serum level that is below or in the lower normal range (based on laboratory-specific reference values), which excludes secondary erythrocytosis associated with an increased serum EPO level (see Differential Diagnosis)

 

[Gianluca]

are you taking Vitamin C with food? when I take it with Food my iron serum goes up when there are no substantial changes on my Ferritin levels, to lower your Iron serum you may try iron cheletor like Vitamin C but on empty stomach or NAC as well

 

[thedeparted]

are you taking Vitamin C with food? when I take it with Food my iron serum goes up when there are no substantial changes on my Ferritin levels, to lower your Iron serum you may try iron cheletor like Vitamin C but on empty stomach or NAC as well

Yes I was taking vitamin c around lunch time daily, which I have stopped at this point.

 

[thedeparted]

So got my Hereditary hemochromatosis result back. Apparently I have one mutation for it, but it takes 2 for it to be significant from what my Dr told me.

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]HEMOCHROMATOSIS RESULT[/TD] [TD="class: valueCol"]One Mutation detected (C282Y)[/TD] [TD="class: rangeCol"][/TD] [TD="class: flagCol"][/TD]

[TD="class: srchbl, colspan: 4"]DNA MUTATION ANALYSIS RESULT: HETEROZYGOUS FOR THE C282Y MUTATION INTERPRETATION: DNA testing indicates that this individual is positive for one copy of the C282Y mutation in the HFE gene. This individual is negative for the H63D mutation. Individuals with this genotype may have elevated serum transferrin iron saturation levels. This result reduces the likelihood that this individual is affected by hereditary hemochromatosis (HH). However, it does not rule out the presence of other mutations within the HFE gene or a diagnosis of HH. The risk of this individual carrying a HFE mutation other than those tested in this assay depends greatly on family and clinical history as well as ethnicity. This assay does not test for other primary or secondary iron overload disorders. Consider genetic counseling and DNA testing for at-risk family members. Hereditary hemochromatosis (HH) is an autosomal recessive disorde r of iron metabolism that results in iron overload and potential organ failure. It is one of the most common genetic disorders in individuals of European-Caucasian ancestry, with an estimated carrier frequency of 10%. HH is caused by mutations in the HFE gene. Most individuals with HH (60-90%) are homozygous for the C282Y mutation. A smaller percentage of affected individuals are either compound heterozygous for the C282Y and H63D mutations (3%-8%), or homozygous for the H63D mutation (approximately 1%). This assay detects the two mutations in the HFE gene, C282Y (NM_000410.2: c.845G>A) and H63D (NM_000410.2: c. 187C>G), that are commonly associated with HH. The mutations are detected by multiplex-polymerase chain reaction (PCR) amplification, followed by digestion of the amplification products with the restriction enzymes Rsal and NlaIII, for the detection of the C282Y and H63D mutations respectively. Fluorescent-labeled restriction fragments are detected by ca pillary electrophoresis. This assay does not detect other mutations in the HFE gene that can cause HH. Since genetic variation and other factors can affect the accuracy of direct mutation testing, these results should be interpreted in light of clinical and familial data.[/TD]

 

[Vince Carter]

I don't see the concern here...Ferritin *should come back given some time and I've never heard how you've here linked Iron and HCG use like you're wanting to change HCG dosing, one has nothing to do with the other that I've ever come across. I think there's a little too much alarm here in your low Ferritin, obvious blood donor I know but I wouldn't be alarmed with those numbers. It is a curiosity how youre running high iron and low ferritin but ferritin does take a fair amount of time to come back.

 

[HealthMan]

So I have a call into Defy after my General Practitioner running labs for my annual physical, but they are closed for the weekend so I was just seeing what you all think of these #'s for now.

I have been doing regular blood donations (3 since last October.) I am currently 3 months on a high dose HCG mono for infertility/low test. And prior to that was 6 months on a low dose Clomid protocol.

Obviously I need to get the iron out of my system, but with the low ferritin my GP Dr doesn't recommend another blood donation. I'm assuming I should back off of the HCG until I can get my Iron back in check?




Component Results

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]WBC[/TD] [TD="class: valueCol"]6.1 K/uL[/TD] [TD="class: rangeCol"]4.0 - 10.7 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]RBC[/TD] [TD="class: valueCol"]5.58 10*6[/TD] [TD="class: rangeCol"]4.20 - 5.60 10*6[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]HEMOGLOBIN[/TD] [TD="class: valueCol"]17.2 GM/DL[/TD] [TD="class: rangeCol"]13.2 - 17.4 GM/DL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]HEMATOCRIT[/TD] [TD="class: valueCol"]49 %[/TD] [TD="class: rangeCol"]38 - 50 %[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCV[/TD] [TD="class: valueCol"]87[/TD] [TD="class: rangeCol"]80 - 98[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCH[/TD] [TD="class: valueCol"]31[/TD] [TD="class: rangeCol"]27 - 34[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MCHC[/TD] [TD="class: valueCol"]35 %[/TD] [TD="class: rangeCol"]33 - 37 %[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]RDW[/TD] [TD="class: valueCol"]12.7[/TD] [TD="class: rangeCol"]8.0 - 18.5[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]PLATELET COUNT[/TD] [TD="class: valueCol"]213 10*3[/TD] [TD="class: rangeCol"]140 - 450 10*3[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]Neutrophils, Absolute[/TD] [TD="class: valueCol"]3.30 K/uL[/TD] [TD="class: rangeCol"]2.00 - 7.30 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]Lymphocytes, Absolute[/TD] [TD="class: valueCol"]1.90 K/uL[/TD] [TD="class: rangeCol"]1.00 - 3.40 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]MONOCYTES, ABSOLUTE[/TD] [TD="class: valueCol"]0.60 K/uL[/TD] [TD="class: rangeCol"]0.00 - 0.80 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]Eosinophils, Absolute[/TD] [TD="class: valueCol"]0.20 K/ul[/TD] [TD="class: rangeCol"]0.0 - 0.5 K/ul[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]Basophils, Absolute[/TD] [TD="class: valueCol"]0.10 K/uL[/TD] [TD="class: rangeCol"]0.0 - 0.2 K/uL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]COMMENT[/TD] [TD="class: valueCol"]Automated differential[/TD] [TD="class: rangeCol"][/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]FERRITIN[/TD] [TD="class: valueCol"]15 ng/mL[/TD] [TD="class: rangeCol"]30 - 400 ng/mL[/TD] [TD="class: flagCol"]L[/TD]

[TH="bgcolor: #006BA6, align: left"]COMPONENT[/TH] [TH="bgcolor: #006BA6, align: left"]YOUR VALUE[/TH] [TH="bgcolor: #006BA6, align: left"]STANDARD RANGE[/TH] [TH="bgcolor: #006BA6, align: left"]FLAG[/TH]

[TD="class: nameCol srchbl"]IRON[/TD] [TD="class: valueCol"]211 ug/dL[/TD] [TD="class: rangeCol"]52 - 150 ug/dL[/TD] [TD="class: flagCol"]H[/TD]

[TD="class: nameCol srchbl"]TIBC[/TD] [TD="class: valueCol"]392 ug/dL[/TD] [TD="class: rangeCol"]240 - 400 ug/dL[/TD] [TD="class: flagCol"][/TD]

[TD="class: nameCol srchbl"]% SATURATION[/TD] [TD="class: valueCol"]54 %[/TD] [TD="class: rangeCol"]15 - 50 %[/TD] [TD="class: flagCol"]H[/TD]

Where you able to fix this?
I have the exact same issue and it looks like it is something called iron avidity. Your body is trying to correct the low ferritin by flooding your blood with iron. My understanding is that in order for your iron levels to normalize your need to bring your ferritin up. So a combination of iron supplementation and less frequent blood donations are needed.