High estradiol after the gel

goga

Member
Hi. After a month of being on the gel (a sachet a I did not feel any better. I checked my hormones and testosterone jumped to the upper third but estradiol has reached the maximum. Sensitive estradiol is not available here. It's a regular one.
I am a primary T deficiency case.
What does it mean? Do I need just to wait?
 
Sensitive estradiol is not available here. It's a regular one.
I am a primary T deficiency case.
What does it mean? Do I need just to wait?

A month on TRT is very early in the game to be expecting even a partial recovery.

When I started Jatenzo, the first week was amazing, followed by 3 weeks of feeling unwell. I didn’t start feeling good until after 2 months even though weight was declining and muscle mass was increasing within only the second week.

Your genetics will determine your individual response to TRT.

In the coming months if you don't feel any better it might mean you need to try injections or you have other problems that are preventing TRT from working.

Do you have any thyroid or any other labs you can share?
 
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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