High E2 (~50 pg/mL) on HCG/Enclomiphene/Anastrozole: Mood, Acne, Fog

Tankeryanker123

New Member
I'm 38, on a fertility protocol/hormone optimization (HCG 250 IU 2x/week, Enclomiphene 12.5 mg daily, Anastrozole) for 80 days. Latest blood work (May 16th 2025): T level at 1376 ng/dL, E2 at 50-55 pg/mL.

Doc said E2 was high, so they increased Anastrozole to 0.25 mg 2x/week ~2 weeks ago. Still having symptoms: low/sad mood, back/shoulder/chest acne, brain fog, some anxiety. The symptoms are somewhat mild but definitely present and noticeable. The acne symptom is heavy though. Is this normal?

I drink ~2-3 drinks (beers/shots) on 2-3 off days/week, which might be keeping E2 high Planning to cut alcohol and discuss with doc soon. Tips for managing mood, acne, fog, or lowering E2?
 
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