High DHEA

Dctrscot

New Member
Hello everyone. I was looking for a little input on something. My protocol is 75 mg of test cyp every 3.5 days. 125 iu hcg daily and .25 mg anastrozole with my shot. All injections are sub q by the way. Labs came in today and are as follows( pertinent I guess, there is more but...)

test 726 ng/dL
shbg 27.10
test free 182 pg/mL
estradiol(ultra sensitive) 29
DHEA - sulfate. 346 ug/ dl. ( range 42-290)

anyone have ave any input as to a reason and is this a concern. I feel great on this protocol. I am not supplementing with DHEA either. Any input is appreciated! Thanks.
 
Hello everyone. I was looking for a little input on something. My protocol is 75 mg of test cyp every 3.5 days. 125 iu hcg daily and .25 mg anastrozole with my shot. All injections are sub q by the way. Labs came in today and are as follows( pertinent I guess, there is more but...)

test 726 ng/dL
shbg 27.10
test free 182 pg/mL
estradiol(ultra sensitive) 29
DHEA - sulfate. 346 ug/ dl. ( range 42-290)

anyone have ave any input as to a reason and is this a concern. I feel great on this protocol. I am not supplementing with DHEA either. Any input is appreciated! Thanks.

May I ask if you added the AI to your protocol as the result of high E2, or have you always been using it, since starting TRT?
 
I have always used it. Unfortunately, prior to finding Nelson, Gene et al, at a much higher rate / dose. I crashed my e2 far too low. For me the combo of sub q injections and smaller hcg doses did wonders.
 
....just to clarify, my .25 mg anastrozole is only with my test shot not everyday. This protocol is almost exact to Crislers' in his new book. Along with Nelson and Gene, I HIGHLY recommend this book. Quick read and great info.
 
i wish i had high dhea. mine as of a few weeks ago was 111 [range 102.6 - 416.3] so the doc has me some dhea/pregnenolone pills coming
 
I've never seen anything bad about high DHEA so I'd stick with it. But I'd let that E2 come up a bit, if considering the T:E ratio, you're at ~25 in a desirable 14-20 range. I'm a huge advocate in not taking Anastrozole if not 100% necessary. Just something to think about. You may be medicating and not need it. But you say you feel great and thats the only thing that matters.
 
If you have endogenous DHEA at those levels that is a sign of excellent conversion of Pregnenolone to DHEA (DHEA-S is the one we measure as the lab for DHEA is very inaccurate).

You're a luck man!
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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