Help: T and E too high, I'm red etc.

goldmember33157

New Member
Hi all,

I've been on TRT a little over a year. Started at 100mg a week; was tested a month in and numbers were still low so i was bumped to 150mg a week. I was tested about 6 weeks after the increase and my total t and free t were considered "optimal" - I believe total was right around 1000 and free was at 170 on my doctors scale, which is exactly where they wanted me; E2 was around 40. Seemed to be going well for a while but about four months after the dose increase I turned red - flushed cheeks and red chest and generally mottled looking skin. My hematocrit/rbc has remained in reference range this whole time. Body acne also got terrible and I seem to be having a lot of trouble losing fat (even on a deficit), especially around the mid section (I've lost about 20 pounds and still have a disproportionate amount of fat around this area, and generally look and feel "soft." More recently I have also been feeling more emotional, anxious, OCD type thoughts with a short temper and maybe some water retention.

I had my one year follow up labs and my Total T was 1268, Free was 300 and something, and E2 was 62. I have since lowered/changed my dose to 125 a week, split between two doses, as of two weeks ago. My question is: are these all hallmark symptoms of everything being too high and needing a dose adjustment? Should the changes I made, with my doctors advice, help resolve these over time as the T and E2 hopefully comes down? Since my E2 was a bit high even prior to trt (hot flashes was one of the symptoms that led me to seek out trt), should I be considering a blocker?

Appreciate any help. I am being retested at the end of the month and if my levels are still high we are reducing the dose to 100mg a week.
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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