Help. Low cortisol and hypothyroid on TRT

douglasmich

New Member
I have been on TRT for 2 years now. 50mg 2x a week test-cyp with no arimidex or HCG.

My last bloods came back with an e2 of 28 and test as 950ng/dl. DOctor was very impressed.

However over last 6 months ive gotton worse on TRT. I had my cortisol checked via 24hr cortisol saliva and it was 50% lower then what it was before TRT.

I now have a hypothyroid aswell with a 35.7C temp in the morning !. I have a script for armour thyroid but i cannot take more then a grain because the low cortisol causes pannick attacks.

I am considering STOPPING TRT because it feels like it has made me worse by ruining my pregnenolone production and screwing up cortisol.

i tried oral pregnenolone 2mg and i felt foggy and bad on it. Im very close to giving up.

Can anyone help me?? thanks.
 
I would not stop TRT, because if you do, your T levels are gonna drop to near zero without a re-start protocol that takes weeks or months. Trust me, you don't want your T levels near zero on top of your current issues.

There are guys here that know a lot about cortisol and thyroid issues and I am sure they can help you.
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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