Help! HCG & Kisspeptin-10 no longer FDA allowable?

Frank777

New Member
I’ve been on TRT for 4 yrs now. I’ve always wanted to keep my HPG axis activated. Began 4 yrs ago also using HCG. Then FDA reclassified it as a biological and could no longer get. Dr substituted peptide Kisspeptin-10. It worked like a champ. Now the FDA is banning that from clinical use because not enough safety studies exist.
so I’ve bben a month with my HOGaxis shut down and it sucks. Libido way down, as well as of course almost no sperm/ejaculate. Not even as sensitive now.

what are you all using with TRT to keep aHPG axis activated?

is Clomid an option to stack on with my TRT?

I hear Netesto nasal TRT does not deactivate HPG axis?

any help would be appreciated!
 
Now the FDA is banning that from clinical use because not enough safety studies exist.
You can still get hCG, just not through compounding pharmacies.

is Clomid an option to stack on with my TRT?
No, not unless on Natesto nasal spray.

In your case, on conventional TRT, it’s hCG of BUST!
what are you all using with TRT to keep aHPG axis activated?
Your HPTA axis is shut down on injectable testosterone and hCG and all other forms of TRT except Natesto and clomid.
 
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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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