HCG Triggered severe hyperthyroidism on TRT

So I had been cruising on TRT with no issues for about 8 years. Starting at .25 ml twice a week from 200mg/ml vials of cypionate. Reducing this down to .14ml over the course of about 2 years.

I wanted to improve my fertility, and began hcg protocol.

I was taking between 600iu to 800iu of hcg about 3 times per week for roughly 6 months. About 2 months in, I had a CT scan of chest for an unrelated issue and they noticed a slightly enlarged thyroid, but didn't think it was an issue.

By month 6, my free t4 hit above the normal range, which prompted my doctor to advise to discontinue.

I discontinued on May 8th completely, but my t3 and t4 have continuously risen since discontinuing.

My last readings:

Free T4 3.8 ng/dl
Free T3 511 pg/dl

I am getting pretty severe symptoms including insomnia, rapid heart rate, major weight loss, and eye pressure.

Has anyone else experienced this from hcg and how did they remedy it?

Got appointment with trt doctor this Wednesday.

I have never had any thyroid issues.

Appreciate any and all advice.

Thanks!
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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