HCG Survey

[MikeXL]

What is your HCG dose? How does it make you feel? Thanks

 

[ERO]

My dose is 200 IU daily - I feel no difference what so ever between using and not using and my testicles seem unaffected as well in terms of size. Much like Testosterone, to me, it feels like I am injecting water.

 

[thatoneguy]

I take 500iu twice a week, can't really say it makes me feel any different. I like to imagine it gives me an energy boost.

I started testosterone and hcg together so can't really compare the difference of just testosterone alone.

While I've been told hcg won't increase testicle size larger then normal, I do feel my testicles are slightly larger then before, and I never had testicle atrophy.

 

[MikeXL]

Why do you do it?

 

[ERO]

To backfill the hormonal pathways is the only reason I use it since I feel nothing at all from it. I have gone without for several weeks, gone back on, etc...it all feels identical.

 

[MikeXL]

Do you test to see if it is infect back filling the pathways ?

 

[Nelson Vergel]

In my non-validated opinion, hCG may not elicit as great of a raise in hydrohyprogesterone, intratesticular (inside the testicle) testosterone, DHT and estradiol in some men compared to better responders (response in increased sperm, testicular volume and sex drive). In particular, hydroxygesterone (an upstream hormone) and intratesticular testosterone are decreased by TRT but increased by HCG. Is the degree of this increase what explains why some men respond better than others to HCG? No one knows.

Is there a direct effect on dopamine by a LH mimicker like HCG? Is there an effect on LH receptors in the brain? So many questions unanswered about HCG's libido and mood enhancing abilities reported anecdotally but not explored in a single study (most just look at sperm production or stimulation tests).

Two studies:


"The effects of human chorionic gonadotropin (hCG) on testicular steroid secretion were studied in men during operation upon inguinal hernia. To investigate the rapid testicular response, we drew blood samples from peripheral and spermatic veins at the beginning of the operation, then gave an intramuscular injection of 5000 I.U. of hCG, and took another set of blood samples 30 min after injection. The slow testicular response to hCG was evaluated by taking samples from spermatic and phcripheral veins 4 days following hCG administration. The operation alone led to a significant decrease in spermatic vein levels of pregnenolone, progesterone, 17-hydroxyprogesterone, androstenedione and testosterone in 30 min. Testicular steroidogenesis responded rapidly to hCG stimulation, which was reflected in elevated spermatic vein levels of pregnenolone, progesterone, 17-hydroxyprogesterone, androstenedione, testosterone and 5α-dihydrotestosterone at 30 min following hCG. In peripheral vein, the concentrations of pregnenolone, progesterone and 17-hydroxyprogesterone were significantly elevated at the same time. Four days following hCG administration, the peripheral serum concentrations of 17-hydroxyprogesteone. testosterone, 5α-dihydrotestosterone and estradiol were significantly increased. In spermatic vein, the steroids released after 4 days suggested a preferential release of C19 steroids and estradiol. Our results directly demonstrate that the human testis is able to respond rapidly to hCG stimulation. The first effect of hCG might be general facilitation of C21 and C19 steroid release to the circulation. Four days after hCG stimulation, the secretion of C19steroids (including testosterone) and estradiol seems to be preferred, with a relative decrease in the release of C21 steroids."

http://www.sciencedirect.com/science/article/pii/0022473182901789


"Objective

To determine if serum concentrations of testosterone precursors would correlate with intratesticular testosterone (ITT) concentration measured directly by testicular aspiration and allow for a less invasive means of inferring ITT.
Design

Controlled clinical study.
Setting

Healthy volunteers in an academic research environment.
Patient(s)

Twenty-nine normal men.
Intervention(s)

We determined ITT concentration by testicular aspiration before and after treatment in men receiving exogenous T to block endogenous gonadotropin production and randomly assigned to one of four doses of hCG (0, 125 IU, 250 IU, or 500 IU every other day) for 3 weeks.
Main Outcome Measure(s)

The association between serum 17-hydroxyprogesterone (17OH-P), androstenedione, and DHEA and ITT.
Result(s)

With T administration alone, serum 17OH-P decreased significantly and increased significantly when 500 IU hCG was administered. End-of-treatment ITT strongly correlated with serum 17OH-P. Moreover, serum 17OH-P, but not androstenedione or DHEA, was independently associated with end-of-treatment ITT by multivariate linear regression.
Conclusion(s)

Serum 17OH-P is highly correlated with ITT in gonadotropin-suppressed normal men receiving T and stimulated with hCG. Serum 17OH-P is a surrogate biomarker of ITT and may be useful in research and in men receiving gonadotropin therapy for infertility."
http://www.sciencedirect.com/science/article/pii/S0015028207005298

 

[Jay]

350 3x a week, and the next morning I generally get wood!

 

[trt4me]

100 daily for now.
I one of those that gets shutdown hard and my testes def go down in size and hurt while it happens.
This dose stops the decrease and pain but doesn't increase them.
I need a larger dose to firm them up and add a little size.

 

[Vince Carter]

To backfill the hormonal pathways is the only reason I use it since I feel nothing at all from it. I have gone without for several weeks, gone back on, etc...it all feels identical.

I have to same its the same for me with the added component of cosmetics...not having the outward appearance of shrunken nuts. I use 250iu 2xw.

 

[Weasel]

I use 400IU mwf. I believe it helps keep my DHT levels up. thus libido and ability up as well.

 

[trt4me]

anyone else try daily and ditch it for a 2-3 x a week schedule?

 

[Vince Carter]

Ive done it all...100 daily, 250 EOD, 250 2XW, 400 EOD, 750 even...all I KNOW i got from it was aggravated E2 as the E2 the converts in the testes is tougher to control with an AI in that particular evironment even though the aromatization is the same.

 

[You Gonna Learn Today]

I'm taking 500iu E3.5D. I was prescribed 1,500iu once per week, but after reading several posts (including Dr. Saya's studies) on here I figured it was best to take 500iu twice per week.

When I wasn't taking HCG, I would get shrinkage quite a bit. Also, before I was only on TCyp without HCG. I didn't feel the wood I'm feeling now that I'm on HCG.

 

[Vince]

I also use 500iu of HCG every 3 1/2 days. I think if you are on TRT, you need HCG.

 

[Nelson Vergel]

Like Vince, I use 500 IU twice per week plus 75 mg twice per week of T

 

[PAUL-E]

I have done 500iu 2x a week M,Th and now 300iu 3x a week M,W,F both are far better than 0. It has helped mood, testical size, erection quality, and even my penis hangs more looks bigger.

 

[You Gonna Learn Today]

That's one thing I also didn't mention, but didn't know if it was related to HCG or not. I have noticed the same for me about how it's hangin. It didn't do anything to my erection size (wishful thinking), but definitely changed my flacid size and always seems like it's "full". That's normally something people don't like to talk about, but hey....this is a health forum, right?

 

[hfbjr]

How many months in did you guys notice a size difference? Reason I'm asking, is that nothing has changed on me yet size wise -I'm in my 9th week

 

[DeMegaMan619]

500 every 4th day