Good to hear it was cutting edge TRT just a couple years ago. Original doc may have wanted me on 100mg once a month. I'm feeling pretty good on Monday only injections, but definitely less energy Saturday and Sunday.
I experienced the same day 5, 6, 7 drop when I was on weekly, and upping my dose helped temporarily - but morning wood went from 3-4 days per week to 1 day per week with higher doses.
E3.5D makes total sense when you understand the science.
Cypionate peaks at 48-72 hours and its half-life is 8 days.
Your current program = big dose that peaks and has huge crash.
Wouldn't it be better if peak & trough were 900-700 range instead of 1,200-400 range?
Also as T spikes with larger dose - so does estrogen.
Wouldn't keeping estrogen in a tighter range also be good?
You said, "Some guys like that feeling from a bigger single dose of T."
Are highs & lows what we should want? Or should achieving an optimal steady state be the goal?
"Guys with higher SHBG may also like once a week injections."
Maybe for a few, but I'm just not sure the science backs up weekly doses for the large majority.
Just because weekly works, does not mean its producing the best possible results.
Post some labs. What is your SHBG, Estradiol-Sensitive, etc?
Good luck with what ever you decide.