HCG Protocol recommendations

Mike9876

Member
I have been on TRT for about 7 months. Up until this point I have only been taking Test Cypionate. I started HCG just over a week ago. My plan was to add in 250iu HCG twice a week, which is what I've done so far. I currently do my test injections EOD so I've planned to do HCG either Monday and Friday OR Tuesday and Saturday. That is, do my HCG injection on a day that I don't do my Test injection. For example, on weeks where my Test injection falls on Mon/Wed/Fri/Sun, I'll do HCG on Tuesday and Saturday, and vice versa.

But, I'm wondering if, because of my low SHBG (21, 23, 22, 25) on 4 blood tests, I'm better off doing HCG 3 times a week.

Suggestions?
 
Vince Carter, I had my blood taken a couple of days ago to get my E2 checked (sensitive test). I should have the results by tomorrow hopefully.

Vince, is this what you do? I've seen a lot of people saying they do HCG on non-Test injection days.
 
Vince Carter, I had my blood taken a couple of days ago to get my E2 checked (sensitive test). I should have the results by tomorrow hopefully.

Vince, is this what you do? I've seen a lot of people saying they do HCG on non-Test injection days.

My line of thinking here is that if E is a problem I would use less HCG, not more. At any rate you can dose it how you like there's really no strategy involved here with HCG.
 
If you have secondary hypogonadism it's best that you take inject 500IU as that dose stimulates your testicles to produce testosterone much more effectively than a 250IU dose. I inject 600IU HCG three times a week. It took a while for my testicles to respond to the HCG, but after a few months at this protocol my testicles responded and produced more testosterone so I reduced the amount of exogenous testosterone I inject.
 
Thanks for that Simon. I have read that injecting 500iu or more of HCG can desensitise the leydig cells. However I've seen other doctors say this isn't the case. What's your take on this?
 
That was an old myth. However, there is no point in taking more hcg iu than the amount needed to stimulate your testis.

See the following link on how the 500iu dose is much better at stimulating the testes than a 150iu dose:

Defy Medical Centers
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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