HCG and Free Testosterone
- Thread starter MikeXL
- Start date
Vince Carter
Banned
Only way you'd know is if you're on HCG mono which ain't too many people.
well. I am on TRT and HCG and have noticed a decline in free t percentage which is why I ask. Before I pull the plug on HCG I would like to know if anyone else has the same observations
Vince
Super Moderator
There are number of disease states that can increase blood levels of SHBG and therefore lower free T levels.
1.Testicular cancer,
2.Breast cancer, fibrocystic breast disease,
3.Elevated estradiol levels,
4.Elevated thyroid levels,
5.Aging,
6.Extreme weight loss as in anorexia nervosa.
7.Pregnancy,
8.Estrogen containing birth control pills,
9.Diets low in protein. In elderly men ages 40 to 70 years. Increased SHBG leads to lower FT and increased risk for fragility, low bone density, fractures, anemia, decreased sexual function etc. [J Clin Endocrinol Metab. 2000 Jan; 85 (1) 293-6]
10.Certain meds such as the Dilantin (a phentyoin) drug class, which can produce increased activity of the enzyme for SHBG synthesis.
11.Liver chirrosis (fibrosis) occurs from scar tissue in the liver , usually formed from excess alcohol abuse or maybe other drugs or chemicals over time. Liver chirrosis is associated with increased SHBG,
12.Cigarettes smoking leads to increased SHBG,
13.Any compromise of liver detoxification such as alcohol abuse, certain meds, heavy metals etc can decrease liver capacity to excrete excess estrogens from the body,
14.Any estrogen use, maybe even the plant estrogens (phytoetrogens) can increase SHBG,
15.Increased conversion T to E (aromatization).
https://www.excelmale.com/forum/sho...adiol-and-Sex-Hormone-Binding-Globulin-in-Men
1.Testicular cancer,
2.Breast cancer, fibrocystic breast disease,
3.Elevated estradiol levels,
4.Elevated thyroid levels,
5.Aging,
6.Extreme weight loss as in anorexia nervosa.
7.Pregnancy,
8.Estrogen containing birth control pills,
9.Diets low in protein. In elderly men ages 40 to 70 years. Increased SHBG leads to lower FT and increased risk for fragility, low bone density, fractures, anemia, decreased sexual function etc. [J Clin Endocrinol Metab. 2000 Jan; 85 (1) 293-6]
10.Certain meds such as the Dilantin (a phentyoin) drug class, which can produce increased activity of the enzyme for SHBG synthesis.
11.Liver chirrosis (fibrosis) occurs from scar tissue in the liver , usually formed from excess alcohol abuse or maybe other drugs or chemicals over time. Liver chirrosis is associated with increased SHBG,
12.Cigarettes smoking leads to increased SHBG,
13.Any compromise of liver detoxification such as alcohol abuse, certain meds, heavy metals etc can decrease liver capacity to excrete excess estrogens from the body,
14.Any estrogen use, maybe even the plant estrogens (phytoetrogens) can increase SHBG,
15.Increased conversion T to E (aromatization).
https://www.excelmale.com/forum/sho...adiol-and-Sex-Hormone-Binding-Globulin-in-Men
Vince Carter
Banned
That's more likely an SHBG issue than HCG, every man on TRT should be on HCG and Free T isn't one of those reasons.
Vettester Chris
Super Moderator
Agree with Vince Carter! HCG will promote the testosterone and increase total serum levels (all depending on leydig function) ... Free testosterone will be factored at that point primarily by SHGB and somewhat by albumin.
I've been on 80mg Cyp x2 + 500U HCG x2 for about 10 weeks now (and was on 200mg biweekly for 4 weeks before that - was with a horrible urologist). Free went from 6.5 to 19.6 and SHBG has decreased from 80.2 to 62.4. Obviously I'm on the combo therapy, but I've been happy with the effects. (Total went from 498 to 1,383).
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