First Post -Avice Requested

[Finallycured]

Hi,

First time posting. I am very confused about what happened after I took Adex for first time. And, what happened after I stopped taking it. I need some help. Here is history and current issue:

Am 52. Started trt last sept. T was 186. E not tested. I will never know why, but doc started me at 400 mg T Cyp every 2 weeks. Within 6 weeks, all ED and depression issues totally gone. Best have ever felt. I started reading and became concerned about e2. He doesn't test for it; just doesn't think it's necessary (still, first primary care that ever tested my T plus he started the shots....). I went to uro doc for 2nd opinion; e2 via Quest sensitive (not the lc/ms/ms) was 40. He suggested dropping dose to 300mg T twice a month (he contacted my primary). At 300mg, ed was back, depression back. Primary returned it to 400mg. Felt great again.

But I was still concerned about e2. He told primary to give me adex 1 mg 3 x week. Mood stayed ok but total loss of sex drive. I only took 3 doses (this was six weeks ago) and stopped. After a month, virtually no improvement. I assumed e2 was totally crashed so paid for Labcorp test for T and Total e myself (I know but need something affordable as a benchmark). Results: Estrogens, Total 207 High scale pg/mL 40 - 115 , and T total 885.7 scale 348-1197 ng/dl So now, my e2 is obviously high. My questions- did the adex (again, only took 1mg three times during one week) tank e2 then totally stopping it caused it to shot up? Meaning, for me, possible that symptoms of high and low e2 are the same (ed, depression, no morning wood)? Having no idea what to do, I took .25 adex yesterday and plan is to take .25 eod. Obviously, no improvement yet. Please, any suggestions/ideas welcome. To be clear, my doc agrees with the uro doc to take 3mg 3 times per week but this is what started the trouble. Thanks!

[TD="class: ccrItemText"]Hi, First time posting. I am very confused about what happened after I took Adex for first time. And, what happened after I stopped taking it. I need some help. Here is history and current issue: Am 52. Started trt last sept. T was 186. E not tested. I will never know why, but doc started me at 400 mg T Cyp every 2 weeks. Within 6 weeks, all ED and depression issues totally gone. Best have ever felt. I started reading and became concerned about e2. He doesn't test for it; just doesn't think it's necessary (still, first primary care that ever tested my T plus he started the shots....). I went to uro doc for 2nd opinion; e2 via Quest sensitive (not the lc/ms/ms) was 40. He suggested dropping dose to 300mg T twice a month (he contacted my primary). At 300mg, ed was back, depression back. Primary returned it to 400mg. Felt great again. But I was still concerned about e2. He told primary to give me adex 1 mg 3 x week. Mood stayed ok but total loss of sex drive. I only took 3 doses (this was six weeks ago) and stopped. After a month, virtually no improvement. I assumed e2 was totally crashed so paid for Labcorp test for T and Total e myself (I know but need something affordable as a benchmark). Results: Estrogens, Total 207 High scale pg/mL 40 - 115 , and T total 885.7 scale 348-1197 ng/dl So now, my e2 is obviously high. My questions- did the adex (again, only took 1mg three times during one week) tank e2 then totally stopping it caused it to shot up? Meaning, for me, possible that symptoms of high and low e2 are the same (ed, depression, no morning wood)? Having no idea what to do, I took .25 adex yesterday and plan is to take .25 eod. Obviously, no improvement yet. Please, any suggestions/ideas welcome. To be clear, my doc agrees with the uro doc to take 3mg 3 times per week but this is what started the trouble. Thanks!

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[ERO]

It is no wonder you feel awful - your TRT protocol is a hot mess. First of all, you should be injecting your Test every 3.5 days at a maximum interval. Next Adex is VERY powerful, so your doctors dose of 3mg per week is crazy and 3mg 3 times a week is insane. Most guys that need Adex need like 0.25mg or less twice a week.

Your best next step is to get a new doctor for TRT that has a clue. Seriously.

 

[Finallycured]

Ero, the actual adex dose was 1 mg, not 3mg. A typo, my mistake. Taking that into account, does it look my idea of .25 eod might help or should I start with even less of a frequency (3 x week)? Thank you!

 

[ERO]

Before anything else, I would start injecting Test every 3.5 days as the shorter interval means less E2 conversion, plus more even T levels. You might not even need an AI after that switch alone. Wait 4-6 weeks and then run blood work again, or you are sure you need an AI, start with 0.25 mg every 3.5 days.

Injecting T once a month is borderline malpractice. All the best TRT docs have their guys injecting every Test 3.5 days or even more often. So in your case instead of 400mg once a month, do 50mg twice a week on say, Monday morning and Thursday evening as an example.

 

[Finallycured]

Interesting. I didn't know more frequent injections = less E2. I just called, he (his nurse) said do every week if I am willing. Again, primary issue with me is depression. She said it's a frequent request to help keep mood stable. So, dose is now 200 mg/week for a total of 800 mg/month (no change to monthly total).

So T is 885.7, E total is 207 on Labcorp scale of 40-115. Even though the E test isn't the best choice, does anyone else agree my feeling awful is probably the E? And that .25 arimidex twice a week might help to lower it (but not crash it)?

 

[CoastWatcher]

Interesting. I didn't know more frequent injections = less E2. I just called, he (his nurse) said do every week if I am willing. Again, primary issue with me is depression. She said it's a frequent request to help keep mood stable. So, dose is now 200 mg/week for a total of 800 mg/month (no change to monthly total).

So T is 885.7, E total is 207 on Labcorp scale of 40-115. Even though the E test isn't the best choice, does anyone else agree my feeling awful is probably the E? And that .25 arimidex twice a week might help to lower it (but not crash it)?

I wonder why you need that much testosterone. Smaller doses injected more frequently might well eliminate the need for an AI while still giving you healthy levels of testosterone. I also wonder about your doctor - you aren't being well served.