Exercise Can Increase Liver Function Tests

If you have recently started a vigorous workout routine in addition to your TRT/HRT (Which I highly recommend, if you are able) make sure you inform your physician and or clinician as your base line chemistry can and will change. I have personally seen a clinical significance with my ALT and AST which correlates directly to my new exercise regimen.


Here is some study data on the topic.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291230/
 
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The key point, in the study that you presented, was that they used moderately active individuals who performed NO intensive weight-training prior to the study. Then they had the subjects perform intense weight-training immediately prior to the assessment period. Therefore, the patient would have to start both TRT and intense weight-training simultaneously for the blood-work to show the most significant asymptomatic elevations of clinical chemistry. The study would have been much more informative had they included a group that was continuously performing intense weight-training prior and during the clinical assessment, for comparison purposes. However, I agree with you (and the conclusion of the study) that one should inform the physician of their current activity as well as abstain from weight-training (especially those starting a new weight-training program) for at least 7 days prior to clinical chemistry assessment.
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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