Estrogen

Depends on what type of anti-estrogen is being used (SERM vs AI?)

Give us some background on your TRT status. What is your protocol, levels, etc?
 
I was at 1400 on a 2 week Testosterone dose that 1400 is testosterone. I am now doing 2 weekly injects but my estrogen is up. Anastrozle is being used sorry for spelling. I am around 50 on the E which I know people are higher but obviously it's affecting me more feel a tad better but the symptoms I am having are all high estrogen. I know the 1400 is high but a mega t shot obviously was dealing with an old school Dr with Defy now just curious how long it normally takes to get the Estrogen balanced. From judging and not trying to play Dr on google etc.. And blood work as other things are normal it's showing the Estrogen is high rest ok except one more thing I have to pull the blood work

LH I think and someone made mention of adding clomid every 10 weeks but I am following what Defy says just saying I have heard some say to add clomid to keep LH going I am on HCG now 350iu 3 weekly.
 
AI's work very quickly and it could lower your E2 in a the matter of a couple of weeks.

Anastrozole has about a 50 hour half life.

Best time to take an AI is 24 hours after your Testosterone injection.

Was your estrogen lab the "Sensitive" lab? If not, you don't have a true E2 value if it's the standard E2 lab designed for women.

You can't add Clomid to a Testosterone protocol; it's one or the other but never combined.

Do as your Physician instructs you; you're in good hands at Defy.
 
Defy asked me to take the AI on the same day of the TestCYp shot. Gene why do you say to take it after 24 hours, is it becuase it creeps up in 24 hours?
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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