Does cabergoline negate prolactin increase after ejaculation?

Dwayne337

New Member
I'm wondering how exactly cabergoline works. I know it'l reduce your current prolactin levels after taking it. But what about ejaculating - will prolactin rise like it normally does, or does caber negate that as well?
 
Cabergoline is a dopamine receptor agonist, meaning it stimulates these receptors the same way dopamine does. Lactotropic cells produce prolactin. These cells accept dopamine as a signal to produce less prolactin. Therefore, cabergoline creates negative feedback just like dopamine, reducing prolactin output.

From this my guess is that cabergoline reduces the output of prolactin at all times, and while spikes after ejaculation still occur, they are reduced in magnitude.
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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