Epigenetic Sperm Quality Test (SpermQT)

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Inherent Biosciences Launches Path Fertility - Epigenetic Sperm Quality Test (SpermQT)

*SpermQT analyzes the molecular function of sperm and is 6x more predictive of fertility potential than standard semen analysis


SALT LAKE CITY, Oct. 18, 2021 (GLOBE NEWSWIRE)
-- Inherent Biosciences, a molecular diagnostics company at the intersection of epigenetics and artificial intelligence (AI), today announced the launch of Path Fertility's Epigenetic Sperm Quality Test, SpermQTTM at the American Society for Reproductive Medicine Scientific Congress & Expo.

"One in eight couples experience infertility and historically the focus of testing, treatment, and the burden has been on the female partner," said Kristin Brogaard, Ph.D., co-founder and COO of Inherent Biosciences. "50% of infertility is due to male factors and the standard semen analysis is a poor and rudimentary diagnostic test with only about 15% sensitivity."

SpermQT analyzes epigenetic patterns (DNA methylation) on genes associated with sperm production, sperm maturation, and embryo development. The test was validated with data from over 2,000 semen samples showing a sensitivity of 84% in predicting the need for In Vitro Fertilization (IVF) treatment. A detailed white paper describing the development and validation of SpermQT is available for download at pathfertility.com. A manuscript is in preparation for peer-reviewed publication.

"There has been little innovation in semen analysis for decades," mentioned Dr. Larry Lipshultz, internationally renowned urologist and clinical advisor to Inherent Biosciences. "I'm most excited about epigenetics, and the data we're seeing for SpermQT shows tremendous promise."

SpermQT is a physician-ordered test with an at-home specimen collection kit. Specimens are shipped to a CAP-accredited and CLIA certified laboratory for analysis. Results are reported as "High Risk" or "Low Risk" for poor sperm quality. The validation data showed that 84% of men with a "High Risk" result required IVF treatment. And, there was a statistically significant lower live birth rate when undergoing Intrauterine Insemination (IUI) treatment (p=0.025).

"We now have a diagnostic that significantly improves the measurement of sperm quality,"
said Alex Pastuszak, MD, Ph.D., Inherent Biosciences clinical advisor. "SpermQT provides reassurance for patients to move forward with natural or assisted conception."

For clinicians interested in offering SpermQT to patients, go to pathfertility.com/providers to request a copy of the white paper, an example report, and a test requisition form.
 

Attachments

*SpermQT analyzes the molecular function of sperm and is 6x more predictive of fertility potential than standard semen analysis

*There has been little innovation in semen analysis for decades," mentioned
Dr. Larry Lipshultz, internationally renowned urologist and clinical advisor to Inherent Biosciences. "I'm most excited about epigenetics, and the data we're seeing for SpermQT shows tremendous promise
 

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Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

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