Endocrine Disrupting Chemicals (Part 2)

madman

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Summary

Researchers discuss the impact of endocrine disrupting chemicals (EDCs), specifically para and poly floral alkyl substances (PFAS), on reproductive health and child development.


Key Takeaways:
  • The presentation discusses the presence of endocrine disrupting chemicals (EDCs), particularly PFAS, in the environment and their effects on human health.
  • PFAS are persistent chemicals that have been widely used and have been linked to metabolic disease, obesity, reproductive health issues, and adverse effects in children.
  • The presentation focuses on studies conducted on human fetuses and young children to evaluate their exposure to PFAS.
  • Studies show that PFAS can be found in maternal serum, placenta, fetal organs, and breast milk, indicating various exposure pathways.
  • Longitudinal studies found that PFAS levels in infants remained stable or slightly decreased over time.
  • Exclusive breastfeeding was associated with higher PFAS levels in infants compared to formula-fed infants.
  • Maternal characteristics such as age and breastfeeding duration were found to be associated with higher PFAS levels in infants.
  • The presentation emphasized the importance of breastfeeding despite the potential exposure to PFAS in breast milk due to its known health benefits for infants.
  • The studies recommended further research to investigate the long-term effects of PFAS exposure during early life.
  • There is evidence of a gradual decrease in PFAS levels in the general population, but hotspots with high levels still exist, emphasizing the need for ongoing regulation and monitoring.
 

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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