This is a transcript of a talk on endocrine disrupting chemicals (EDCs) and their impact on the endocrine system. The talk is part of the ESC Talks series, focusing on EDCs. The speaker introduces the topic and the speakers for the day, highlighting the importance of addressing EDCs in the endocrine community. The talk provides definitions and background information on EDCs, including their effects on hormone receptors and various biological processes. It also discusses the complexity of exposure to multiple mixtures of EDCs and the non-linear relationship between exposure and response. The talk emphasizes the need for further research and the implementation of strategies to address EDCs.
Highlights
The focus of the talk is on endocrine disrupting chemicals and their impact on reproductive health.
The talk includes information on the definition and characteristics of endocrine disrupting chemicals.
The speaker emphasizes the importance of understanding the effects of these chemicals on the endocrine system.
Evidence is presented on the declining fertility rates and increasing incidence of endocrine-related disorders.
The speaker highlights the role of environmental exposures, particularly endocrine disrupting chemicals, in these health issues.
The focus then shifts to the specific role of toxic metals in reproductive health.
Data from human and animal studies is presented to show the association between toxic metal exposure and hormone levels.
The speaker discusses the use of benchmark dose modeling to determine the dose-response relationship between toxic metals and hormones.
The potential protective effects against the combined exposure to toxic metals are addressed, suggesting a healthy balanced diet and lifestyle as preventative measures.
The presentation concludes with the need for further research and understanding of the mechanism behind the effects of toxic metals on reproductive health.
Predict estradiol, DHT, and free testosterone levels based on total testosterone
⚠️ Medical Disclaimer
This tool provides predictions based on statistical models and should NOT replace professional medical advice.
Always consult with your healthcare provider before making any changes to your TRT protocol.
ℹ️ Input Parameters
Normal range: 300-1000 ng/dL
Predicted Hormone Levels
Enter your total testosterone value to see predictions
Results will appear here after calculation
Understanding Your Hormones
Estradiol (E2)
A form of estrogen produced from testosterone. Important for bone health, mood, and libido.
Too high can cause side effects; too low can affect well-being.
DHT
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth,
prostate health, and masculinization effects.
Free Testosterone
The biologically active form of testosterone not bound to proteins.
Directly available for cellular uptake and biological effects.
Scientific Reference
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
