Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

Vince

Super Moderator
If you're taking statins you might want to reevaluate this decision. “Mitochondria and the Future of Medicine” a chapter on mitochondrial involvement in neurodegeneration provides evidence that statins may be causal in many serious diseases such as ALS/MND, Parkinson’s Disease, Alzheimer’s disease, MS, etc. Statins block mevalonate synthesis, they lower levels of CoQ10, an essential compound for mitochondrial energy production, as well as lowering cholesterol. M. Flint Beal, a prominent neurologist, has spent years proving that CoQ10 has neuroprotective properties that might help diseases such as Parkinson’s and Huntington's and a growing body of scientific evidence supports his hypothesis. Research has established that mitochondria from platelets in patients with early, untreated Parkinson’s had reduced activities of Mitochondrial Complexes I, II and III.

There are conflicting opinions about CoQ10 supplementation. It's unlikely to harm you even at a higher dose of 1200 mg/d. Ubiquinol (CoQ10) is used in the ETC of mitochondria.

 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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