Effectiveness of micronized purified flavonoid fraction on venous symptoms and signs in patients at all stages of chronic venous disease

[madman]

Conclusions

This large systematic review and meta-analysis of RCTs and non-RCTs focusing on CVD symptoms demonstrates that daily treatment with MPFF 1000 mg leads to signifi cant symptoms improvement in patients with CVD at all stages of the disease. In addition, high levels of satisfaction (at least 90%) with MPFF treatment were reported by patients. These findings provide robust evidence of significant symptomatic benefit with MPFF in a wide range of patient profiles across all classes of CVD.