The Science Behind MPFF (Micronized Purified Flavonoid Fraction)

madman · Apr 27, 2025

MPFF (Micronized Purified Flavonoid Fraction) is a well-researched combination of bioflavonoids, including Diosmin and Hesperidin. For 40 years, it has been studied for its role in supporting venous and lymphatic function.

Dr. Chuback breaks down how MPFF works and why it holds a 1A recommendation from the American Venous Forum.

madman · Apr 27, 2025

The Healthy Veins Book | American Venous Forum

www.venousforum.org

Understanding Varicose Veins and Leg Swelling

Improper blood flow caused by venous disease

madman · Apr 27, 2025

Thread 'New Perspectives on Micronised Purified Flavonoid Fraction in Chronic Venous Disease'

Dec 27, 2022

New Perspectives on Micronised Purified Flavonoid Fraction in Chronic Venous Disease: From Microvalves to Clinical Effectiveness (2022)
Eliete Bouskela . Marzia Lugli . Andrew Nicolaides

ABSTRACT

The importance of chronic venous disease (CVD), as a cause of reduced quality of life and increased costs to healthcare systems, is expected to rise in parallel with population aging and the increasing prevalence of obesity. Venoactive drugs (VADs) are frequently used to treat the symptoms and signs of CVD. The most commonly used and widely studied VAD, micronized...

madman · May 3, 2025

Thread 'The Effects of Different Dosages on Micronized Purified Flavonoid Fraction’s Treatment of Lower Limb Chronic Venous Disease'

May 3, 2025

* In symptomatic chronic venous disease patients, MPFF 1000 mg once daily and MPFF 500 mg twice daily improve patient compliance, lower limb discomfort, clinical adverse events, and quality of life scores similarly.

Abstract

Background

Micronized purified flavonoid fraction (MPFF) is a widely prescribed and extensively investigated venoactive drug (VAD). The standard dosage for MPFF is 500 mg administered twice daily. However, a new daily dose of 1000 mg has just been introduced.

Objective

This study investigated whether...