E2 keeps climbing slowly over several months on EOD injections

Tylurnt

New Member
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Above is
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above is Most recent test at 28-30mg EOD.

Below is test from end of July at 24-26mg EOD.

Yes I feel like shit, and my shbg was 9.8! Im doing subq EOD and just recently am trying ED injections. I dont understand how my e2 has trippled? Does anyone have any input on this? What route should I go to get it down? I do not want to take an AI, obviously need to lower my dose cause my Free T was too high and I was definitely feeling it... fight or flight feeling and just feel like crap. Felt so much better taking a break from injections but even starting at a lower dose, started feeling like crap again.




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Stick the needles into your delts and ventroglutes and depress the plunger. Run labs again in 6 weeks. Try to refrain from starting new threads in the meantime.
 
It's possible that your body slowly adjusts the aromatization of T to E. Now your fT as well as your E is high. That's normal. Also sometimes the E lab test overestimates.
My suggestion: reduce the dose and bring your fT in range (around 20pg, maybe you can get there with 60-70mg T per week). The adjustment will take time.
Or go with @FunkOdyssey suggestion.

Did you have that low shbg before starting TRT?
 
It's possible that your body slowly adjusts the aromatization of T to E. Now your fT as well as your E is high. That's normal. Also sometimes the E lab test overestimates.
My suggestion: reduce the dose and bring your fT in range (around 20pg, maybe you can get there with 60-70mg T per week). The adjustment will take time.
Or go with @FunkOdyssey suggestion.

Did you have that low shbg before starting TRT?
I dont know, didnt have it tested until my first test. It was 11. Something 6 weeks from starting. Doesn't e2 take a long time to go down? Will it take a while to lower it after lowering my dose? I started 10mg eod but that felt too much, so I havent had an injection since Wednesday morning. Gonna go down to 8mg tomorrow probably. Im doing Test E
 
I dont know, didnt have it tested until my first test. It was 11. Something 6 weeks from starting. Doesn't e2 take a long time to go down? Will it take a while to lower it after lowering my dose? I started 10mg eod but that felt too much, so I havent had an injection since Wednesday morning. Gonna go down to 8mg tomorrow probably. Im doing Test E
E2 follows T. Adjustment of aromatization might take a while. You could skip a week of injections, this might give your body more time for clearance of E2.
I would then continue with 60-70mg split into two sc injections per week. If you feel better with eod or ed, then do that.
 
I started 10mg eod but that felt too much, so I havent had an injection since Wednesday morning
If 35 mg weekly feels like too much, take that as strong evidence that something is wrong at a fundamental level, either with you, what you're taking, or how you're taking it.

Insanity is doing the same thing over and over again while expecting different results. This race to the bottom (zero milligrams weekly), continuing to use your current formula, current injection method, current modality, is frustrating for everyone. Frustrating for you to experience and frustrating for us to hear about.

Change something!
 
If 35 mg weekly feels like too much, take that as strong evidence that something is wrong at a fundamental level, either with you, what you're taking, or how you're taking it.

Insanity is doing the same thing over and over again while expecting different results. This race to the bottom (zero milligrams weekly), continuing to use your current formula, current injection method, current modality, is frustrating for everyone. Frustrating for you to experience and frustrating for us to hear about.

Change something!
Sorry, I meant 10mg ED, not EOD
 
If 35 mg weekly feels like too much, take that as strong evidence that something is wrong at a fundamental level, either with you, what you're taking, or how you're taking it.

Insanity is doing the same thing over and over again while expecting different results. This race to the bottom (zero milligrams weekly), continuing to use your current formula, current injection method, current modality, is frustrating for everyone. Frustrating for you to experience and frustrating for us to hear about.

Change something!
Yes working on it. Like I said im switching to every day injections now... did 10mg every day but that caught up to me, so going to stick to 8mg for many weeks and retest... Just worried about getting e2 down
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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