CDC STANDARDIZED TOTAL T and ESTRADIOL ASSAYS and soon to be FREE TESTOSTERONE!

madman · Nov 2, 2025

Thread 'Free T vs Total T - Cutoffs and Symptoms - Where Are the Data?'

Oct 13, 2025

25th Annual Fall Scientific Meeting of SMSNA!

Grapevine, Texas.

1:14:05-1:29:40

Recommendatios for Dealing with Free T

Concept of Total Hormonal Load

Keep in mind all those men with normal TT and high SHBG!

Reasonable, Evidence-based Recommendation for Managing T

madman · Nov 2, 2025

Thread 'How to Avoid a Mad "T" Party: Evaluation and Management of Male Hypogonadism'

Nov 2, 2025

One of the big boys in the field!

Dr. Anawalt!

Pay attention to the Q&A (43:20-56:30) especially when it comes to testing free testosterone!

43:20-46:27 - How do we assess for free testosterone?

* There's a direct antibody assay (IA) that measures free testosterone it is notoriously inaccurate and notoriously underestimates the true free testosterone as much as 30% so you should never use that but it is cheap, its easy, its quick so all labs offer it

madman · Nov 8, 2025

Thread 'Hormone Health at Risk: Why Europe Is Failing to Fund Endocrine Research—and How EndoCompass Aims to Fix It'

Nov 8, 2025

* Standardization and harmonization offer the possibility to make laboratory test results more comparable. Standardization refers to the process of achieving agreement between hormone tests by establishing traceability to a recognized standard reference material through a high-order primary reference material (RM) and/or reference material procedure (RMP); it concerns mainly inert hormones such as steroids.

* The quality of analyses in endocrinology is challenging but crucial. High-quality analyses ensure the reliability of research conclusions and interpretation of patient...

madman · Nov 8, 2025

Thread 'The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)'

Nov 8, 2025

* With CLASH-free, we will improve the clinical applicability of free steroid hormone concentrations in patients with specific conditions by using state-of-the-art methods.

* Formulas to estimate free steroid hormone concentrations are used instead, but their applicability in many clinical conditions is questionable, so is the correctness of therapeutic actions based on these results.

* We will improve current formulas to better estimate free hormone levels.

Research Portal - The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)

Steroid hormones such as testosterone or vitamin D are vital forhuman physiology. In circulation, steroid hormones bind to specificbinding proteins and albumin, with only a small fraction circulatingfreely. The ‘free hormone hypothesis’ suggests that this free fractionis responsible for...

research.kuleuven.be

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