Cannot ejaculate on Enclomiphene & Cialis

[Forty2]

I've been taking enclomiphene for the past 2 weeks.
The first week was at 25mg/day but I dropped the dose down to 25mg eod with 5mg/day cialis this past week because of ED during the first week.
During this last week I've had no ED but cannot ejaculate.
I'm not taking any other meds.
I took enclomiphene solo a year ago at the same dose without a problem, so I'm guessing cialis is the culprit.
Has anyone experienced delayed ejaculation or inability to climax while taking cialis, enclomiphene or a combination of the two?

 

[aneuman]

I took enclomiphene solo a year ago at the same dose without a problem, so I'm guessing cialis is the culprit.

I've always taken them together, and yes, delayed ejaculation was a big problem. I've always thought Cialis had a role in it, as when I was only on Cialis (daily, for BPH) I noticed I started lasting longer, and getting less sensitive, but there may have been other processes at play (such as getting older, T getting lower simultaneously, or E2 getting lower or higher, lower DHT, who knows) without me knowing.

And then I took HCG. All of a sudden, even with cialis, for a short two or three weeks, the heavens opened and all was good. I was 25 again. Nothing could be better. Then it went away.

So I'd argue that even though PDE5-I like cialis does have (and it's documented) an effect in the time it takes to ejaculate, I don't think it is "the" cause, it may compound the problem, but I think EC in my opinion makes it worse.

Conclusions: • The PDE5 inhibitors seem to prolong ELT and the quality of penile rigidity is better with PDE5 inhibitors in post-ejaculatory period. • These findings suggest that PDE5 inhibitors might have some beneficial effects in men with lifelong premature ejaculation.

Has anyone experienced delayed ejaculation or inability to climax while taking cialis, enclomiphene or a combination of the two?

Yes, with Enclomiphene and Cialis labs were great but everything else was horrible. I could maintain an erection for hours but to the point of giving up. Low dose HCG (600IU x 3 /week) made the situation a little bit better, but did not resolve it. TRT is making better improvements. Time will tell.

I recently read the following:

These data strongly point to a role for endogenous DHT in the maintenance of normal sexual and ejaculatory function and sexual desire. And, in fact, this has been shown to be true in healthy young men where serum DHT concentration was revealed to be the sole independent predictor of orgasm frequency, a surrogate for overall male sexual function .

Obviously, although generally healthy, I'm not what most people would consider a "young man" so this may not apply to me.

Here's the source of my citation: Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels

As an anecdote based on posts on this sites, it seems that people on testosterone cream resolve libido, erection, "sensitivity", and orgasm issues very quickly and satisfactory. The one characteristic of topical testosterone treatment is the high conversion of T to DHT on the skin. Just saying.

 

[Systemlord]

I took enclomiphene solo a year ago at the same dose without a problem, so I'm guessing cialis is the culprit.
Has anyone experienced delayed ejaculation or inability to climax while taking cialis, enclomiphene or a combination of the two?

Cialis helped my weak urine stream, tip of penis pulled inside the shaft and would orgasm and ejaculation would never happen.

Without Cialis, I can’t ejaculate, urine stream spays in multiple directions or not at all.

I propose the reason for my ejaculation problem was high estrogen, Cialis’s lowers estrogen.

It’s a mistake to think that your body can’t change over time.

 

[madman]

I've been taking enclomiphene for the past 2 weeks.
The first week was at 25mg/day but I dropped the dose down to 25mg eod with 5mg/day cialis this past week because of ED during the first week.
During this last week I've had no ED but cannot ejaculate.
I'm not taking any other meds.
I took enclomiphene solo a year ago at the same dose without a problem, so I'm guessing cialis is the culprit.
Has anyone experienced delayed ejaculation or inability to climax while taking cialis, enclomiphene or a combination of the two?

PDE5i!

post #2

Overcoming Premature Ejaculation

In this episode, we discuss premature ejaculation, a problem faced by 30-40% of men at some point in their lives. *But what defines premature ejaculation and, for that matter, what is considered a normal time to ejaculation? *10 minutes? 5 minutes? 1 minute? *What causes premature...

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Delayed or Absent Orgasm in Men

12:05-16:00 *I'll be honest often times we really don't know this delayed ejaculation and orgasmia this is probably the least understood and hardest to deal with problems that clinicians such as myself and in general the clinical world come up against and you know and look there are a variety...

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I've been taking enclomiphene for the past 2 weeks.
The first week was at 25mg/day but I dropped the dose down to 25mg eod with 5mg/day cialis this past week because of ED during the first week.
During this last week I've had no ED but cannot ejaculate.
I'm not taking any other meds.
I took enclomiphene solo a year ago at the same dose without a problem, so I'm guessing cialis is the culprit.
Has anyone experienced delayed ejaculation or inability to climax while taking cialis, enclomiphene or a combination of the two?

Daily tadalafil as a treatment for ED and premature ejaculation

ABSTRACT Objective: To evaluate the safety and effectiveness of daily 5-mg tadalafil treatment for men who have erectile dysfunction (ED) and premature ejaculation (PE), and to assess the long-term follow-up for ED and PE improvement persistence years after the cessation of medication...

www.excelmale.com

post #2

Overcoming Premature Ejaculation

In this episode, we discuss premature ejaculation, a problem faced by 30-40% of men at some point in their lives. *But what defines premature ejaculation and, for that matter, what is considered a normal time to ejaculation? *10 minutes? 5 minutes? 1 minute? *What causes premature...

www.excelmale.com

Delayed or Absent Orgasm in Men

12:05-16:00 *I'll be honest often times we really don't know this delayed ejaculation and orgasmia this is probably the least understood and hardest to deal with problems that clinicians such as myself and in general the clinical world come up against and you know and look there are a variety...

www.excelmale.com

 

[madman]

Cialis helped my weak urine stream, tip of penis pulled inside the shaft and would orgasm and ejaculation would never happen.

Without Cialis, I can’t ejaculate, urine stream spays in multiple directions or not at all.

I propose the reason for my ejaculation problem was high estrogen, Cialis’s lowers estrogen.

It’s a mistake to think that your body can’t change over time.

You should very well know by now that this is not a given.

I have been using 5 mg daily for 2 years now and it has never had any impact on driving down my estradiol.

High SHBG, Low Free T, and Libido - Can you help me?

200mg test cyp a week, twice a week injection M/TH 0.125mg Arimidex with injection twice a week. 0.25mg total a week SHBG 49.9 1259 total test Free T 26.4 pg/mL Estradiol ,sensitive 45.4 pg/mL I felt my e2 was low on this and I had brain fog. Irritable, and just depressed. Libido was good...

www.excelmale.com

 

[Forty2]

Thanks for your replies.
I'm now unsure how to proceed from here.
I have tried hCG monotherapy using Pregnyl at 500iu eod and felt great for the first 3 weeks only.
I then tried TRT with hCG for 6 months using different doses and finding that I felt best on 35mg test cypionate and 375iu hCG E3D.
However, during all the time I was on TRT/hCG I had far more episodes of ED than when I was taking nothing at all. Taking low dose cialis made it much more difficult to reach climax and libido was also pretty much non existent like it is taking nothing, so I quit.
Last year I experimented with Enclomiphene for the first time. At 12.5mg eod for 2 weeks, I felt nothing. At 12.5mg daily for the next 2 weeks I felt better and at 25mg daily for the following 2 weeks I felt even better in terms of my energy, mood and workout performance, but no change in libido and I had some problems getting an erection.
This year my body fat is a little higher, which probably means higher estradiol and greater likelihood enclomiphene would give me ED.
My natural testosterone level is at the bottom of the reference range. I'm unsure if I should just live with it or try TRT/hCG again?

 

[Systemlord]

I have not seen you mention at any time in the past that you were on TRT in isolation, always together with hCG.

 

[Forty2]

I have not seen you mention at any time in the past that you were on TRT in isolation, always together with hCG.

I did take TRT on its own for the first 6 weeks out of a total of 6 months. When I added the hCG I felt a lot better.

 

[Systemlord]

I did take TRT on its own for the first 6 weeks out of a total of 6 months. When I added the hCG I felt a lot better.

Maybe all you needed was more testosterone and not necessarily hCG. Lots of guys respond strangely to hCG, at first they feel great, then after a time they feel bad, that’s the nature of hCG for some men.

Men cycle on and off for this very reason.

Also, 6 weeks is a little early to be adding other compounds in to your TRT. You never even tried to dial in on TRT, let alone allow your body time to adapt. You may reach a steady state in 6 weeks, but adapting to this new higher hormones can take longer (12 weeks).

 

[aneuman]

You should very well know by now that this is not a given.

I have been using 5 mg daily for 2 years now and it has never had any impact on driving down my estradiol.

Ditto here, except for almost 5 years now.

 

[Forty2]

I have not seen you mention at any time in the past that you were on TRT in isolation, always together with hCG.

Maybe all you needed was more testosterone and not necessarily hCG. Lots of guys respond strangely to hCG, at first they feel great, then after a time they feel bad, that’s the nature of hCG for some men.

Men cycle on and off for this very reason.

Also, 6 weeks is a little early to be adding other compounds in to your TRT. You never even tried to dial in on TRT, let alone allow your body time to adapt. You may reach a steady state in 6 weeks, but adapting to this new higher hormones can take longer (12 weeks).

I didn't want to adapt to TRT only since I don't want my balls to shrink and don't want to lose sensitivity downstairs.

 

[joemorgan]

I've been taking enclomiphene for the past 2 weeks.
The first week was at 25mg/day but I dropped the dose down to 25mg eod with 5mg/day cialis this past week because of ED during the first week.
During this last week I've had no ED but cannot ejaculate.
I'm not taking any other meds.
I took enclomiphene solo a year ago at the same dose without a problem, so I'm guessing cialis is the culprit.
Has anyone experienced delayed ejaculation or inability to climax while taking cialis, enclomiphene or a combination of the two?

You do not mention your age but I see your name is forty2 so I guess that is it. Inability to ejaculate is a form of ED. It is usually in older men and related to prostate activity or lack thereof. Finasteride is famous for causing lack of ejaculation. Once lost by medication or otherwise it is hard to recover. The volume reduces as we get older and eventually may only be a few drops.
I recommend addressing the prostate by adding zinc with an appropriate copper ratio along with some other supps. Prostate formulas vary from good to useless. Prosta-Strong by Irwins is pricey but look at the ingredients to get an idea of what individual things you can add to the zinc. Pumpkin seeds are high in zinc and you will see the oil in good formulas.
After several weeks of supplemental therapy, do some work on ejaculation by self stimulating and even watch porn if you need to.
When having sex, the striving for climax is the time when susceptible men can get a heart attack. When both have had a good time, you can quit for the day. I would not subject a partner to half-hour of oral just to try and get a climax.
Women generally feel that if you don't climax they did not do a good job. It is usually the man's own ability that is the problem. Let a partner know you have the issue so you can stop after a while and not overdo both of you.
The other issue is the dose of enclomiphene. I consider you are on a high dose. It comes in 6.25, 12.5, and 25. I alternate between 6.25 and 125 but that's just me. I have been doing men's health for about 10 years and have used regular clomiphene a lot. The cis isomer is different and dosing is different.
ALERT for all reading this. If you don't know yet, all oral 5DPEs will stop working after a time of 3-5 years generally but in some can work for up to eight years.
The receptor that reacts to the medication becomes desensitized and will respond less and less to finally nothing. This info is not available on the package insert or on the internet generally. I found this out by having a discussion with an enzyme physiologist, PhD who explained how it works and finally does not work.
I am not on here regular so if you need to contact me- [email protected]

 

[madman]

You do not mention your age but I see your name is forty2 so I guess that is it. Inability to ejaculate is a form of ED. It is usually in older men and related to prostate activity or lack thereof. Finasteride is famous for causing lack of ejaculation. Once lost by medication or otherwise it is hard to recover. The volume reduces as we get older and eventually may only be a few drops.
I recommend addressing the prostate by adding zinc with an appropriate copper ratio along with some other supps. Prostate formulas vary from good to useless. Prosta-Strong by Irwins is pricey but look at the ingredients to get an idea of what individual things you can add to the zinc. Pumpkin seeds are high in zinc and you will see the oil in good formulas.
After several weeks of supplemental therapy, do some work on ejaculation by self stimulating and even watch porn if you need to.
When having sex, the striving for climax is the time when susceptible men can get a heart attack. When both have had a good time, you can quit for the day. I would not subject a partner to half-hour of oral just to try and get a climax.
Women generally feel that if you don't climax they did not do a good job. It is usually the man's own ability that is the problem. Let a partner know you have the issue so you can stop after a while and not overdo both of you.
The other issue is the dose of enclomiphene. I consider you are on a high dose. It comes in 6.25, 12.5, and 25. I alternate between 6.25 and 125 but that's just me. I have been doing men's health for about 10 years and have used regular clomiphene a lot. The cis isomer is different and dosing is different.
ALERT for all reading this. If you don't know yet, all oral 5DPEs will stop working after a time of 3-5 years generally but in some can work for up to eight years.
The receptor that reacts to the medication becomes desensitized and will respond less and less to finally nothing. This info is not available on the package insert or on the internet generally. I found this out by having a discussion with an enzyme physiologist, PhD who explained how it works and finally does not work.
I am not on here regular so if you need to contact me- [email protected]

It is usually in older men and related to prostate activity or lack thereof.

Numerous things can have a negative impact on semen volume.

Aging, low testosterone, certain medications (exogenous T, 5ARis) to name a few.

Majority of the seminal fluid comes from the seminal vesicles (65-75%).

The prostate gland (25-30%), bulbourethral gland (<1%).

Secretions from the testes are only (2-5%) of seminal fluid.

Orgasm intensity and ejaculation volume after trt

I've seen that orgasm intensity is somehow related to ejaculation. The more you ejaculate the more spasms. Also this is also obviously related to ejaculation volume. What happens after trt if it shuts down sperm production? Assume no HCG is being taken or can't be taken.

www.excelmale.com

How to Increase Semen Volume?

Have you been wanting to supercharge your load? What’s in it for you? In today’s video, we will learn proven ways how to boost your semen or ejaculatory volume. Let me know your thoughts. Thanks for watching! ▶️Chapters: 00:00 Intro 00:11 Semen Volume 01:00 5% of ejaculate is sperm...

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Normal physiology of ejaculation

Ejaculation: the Process and Characteristics From Start to Finish (2022) Matthew M. Mason · Kyle Schuppe · Alexander Weber · Aaron Gurayah · Akhil Muthigi · Ranjith Ramasamy Abstract Purpose of Review Semen analysis serves as the initial step in the evaluation of male infertility. However...

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ALERT for all reading this. If you don't know yet, all oral 5DPEs will stop working after a time of 3-5 years generally but in some can work for up to eight years. The receptor that reacts to the medication becomes desensitized and will respond less and less to finally nothing. This info is not available on the package insert or on the internet generally.

I know you mean well but you need to rethink that one.

Your underlying vascular health will play a significant role.

*No evidence has emerged concerning the development of any form of dependence or tolerance with the chronic use of PDE5 inhibitors.


post #69/79/89

Penis smaller after TRT

My advice wasn't for OP only as there seemed to be many others on TRT who noticed shrinkage. Ageing lol? I am 30 years old and I don't have ED. Viagra still gives the wow effect and makes me pop random boners all the time while cialis does not do absolutely anything anymore as I have developed...

www.excelmale.com

0:36-1:07 (PDE5i efficacy/tolerance)

 

[madman]

You do not mention your age but I see your name is forty2 so I guess that is it. Inability to ejaculate is a form of ED. It is usually in older men and related to prostate activity or lack thereof. Finasteride is famous for causing lack of ejaculation. Once lost by medication or otherwise it is hard to recover. The volume reduces as we get older and eventually may only be a few drops.
I recommend addressing the prostate by adding zinc with an appropriate copper ratio along with some other supps. Prostate formulas vary from good to useless. Prosta-Strong by Irwins is pricey but look at the ingredients to get an idea of what individual things you can add to the zinc. Pumpkin seeds are high in zinc and you will see the oil in good formulas.
After several weeks of supplemental therapy, do some work on ejaculation by self stimulating and even watch porn if you need to.
When having sex, the striving for climax is the time when susceptible men can get a heart attack. When both have had a good time, you can quit for the day. I would not subject a partner to half-hour of oral just to try and get a climax.
Women generally feel that if you don't climax they did not do a good job. It is usually the man's own ability that is the problem. Let a partner know you have the issue so you can stop after a while and not overdo both of you.
The other issue is the dose of enclomiphene. I consider you are on a high dose. It comes in 6.25, 12.5, and 25. I alternate between 6.25 and 125 but that's just me. I have been doing men's health for about 10 years and have used regular clomiphene a lot. The cis isomer is different and dosing is different.
ALERT for all reading this. If you don't know yet, all oral 5DPEs will stop working after a time of 3-5 years generally but in some can work for up to eight years.
The receptor that reacts to the medication becomes desensitized and will respond less and less to finally nothing. This info is not available on the package insert or on the internet generally. I found this out by having a discussion with an enzyme physiologist, PhD who explained how it works and finally does not work.
I am not on here regular so if you need to contact me- [email protected]

Pay close attention @2:24-2:59 (The main driver as to why some men are non-responders).

0:20-2:59

post #2

Supercharge Your Health: The Nitric Oxide Revolution!

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