Can HCG and Clomid Be Taken Together?

I'm sure there is a more comprehensive answer than this out there, but the short answer is no. You can take them together but HCG will ultimately render the clomid useless because it will inhibit your body's production of LH through negative feedback. Clomid works by tricking the hypothalamus into thinking that it needs to release more Gonadotropin-releasing hormone, which in turn signals the pituitary to produce more LH and FSH. HCG essentially replaces your body's LH, which means that the pituitary will eventually ignore the signals from the hypothalamus due to negative feedback from the HCG, which it perceives as LH. It may work at first but over time you'll wind up with very low LH due to the HCG. To make matters worse, not only will HCG nullify the testosterone-boosting benefits of clomid, but many of the estrogenic/anti-estrogenic side effects from clomid will remain since the isomers also function independently from their action on the hypothalamus.

Here is a thread that you may find helpful: Combining Testosterone and Clomid
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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