Building a TRT protocol around hCG

Usually my e2 sits between 10-20pg with T only to the point I did inject estradiol valerate to get it up in to the 30-50pg range.
Why did you stop using the estradiol valerate? Were there no subjective benefits associated with the higher E2? I think even if there weren't, you'd probably be safer from a health standpoint running your E2 between 30-50 than 10-20.
 
How would you go about doing cognitive testing?

Regarding supplementation of pregnenolone, DHEA, DHT... This basically says only high doses cross the blood-brain barrier and actually have an effect?
Yes, but you have to take all of it with a grain of salt. It's pretty obvious that taking these hormones can affect how you feel, sometimes very dramatically.

Also, sorry if I missed it, what are your pregnenolone levels natty?
163 ng/dL
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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