Building a TRT protocol around hCG

[FunkOdyssey]

Usually my e2 sits between 10-20pg with T only to the point I did inject estradiol valerate to get it up in to the 30-50pg range.

Why did you stop using the estradiol valerate? Were there no subjective benefits associated with the higher E2? I think even if there weren't, you'd probably be safer from a health standpoint running your E2 between 30-50 than 10-20.

 

[FunkOdyssey]

How would you go about doing cognitive testing?

PsyToolkit’s experiment library

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Regarding supplementation of pregnenolone, DHEA, DHT... This basically says only high doses cross the blood-brain barrier and actually have an effect?

Yes, but you have to take all of it with a grain of salt. It's pretty obvious that taking these hormones can affect how you feel, sometimes very dramatically.

Also, sorry if I missed it, what are your pregnenolone levels natty?

163 ng/dL

 

[dirkdigglr]

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Any specific tests/metrics which you noticed are sensitive to changes?

 

[cjp360]

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All I got out of hCG was a bunch of E2. The preg/prog/17-OHP and presumably allopregnanolone that I was expecting to rise all remained bottomed out. DHT/E2 ratio almost halved.

ChatGPT led me to believe this low dose daily hCG was going to be an efficient way to raise most of the TRT-disrupted neurosteroids into the normal range, but it now claims they are mostly derived from the adrenal glands, and only large bolus doses of hCG are able to produce measurable increases. I think I receive about 50% useful advice and 50% gaslighting from this tool.

similar thing happened to me - on low dose HCG - essentially all I got was e2 from it - and a round face. Bolus doses with more space between sometimes 2 x a week sometimes 3 if im really feeling I need it. Do way way better both lab wise, and feeling wise - than small daily doses. Low daily dose after a while started to atrophy too. preg was crashed - prog was crashed, went back to 2 x 450 or 3 x 400 - and prog went back up prgenenlone and free t rose, e2 stayed somewhat the same or even lower.