Bottomed out and confused

Zooulie12

Member
My protocol is 60mg twice a week Monday and Thursday. I take my anastrolze on Tuesday ‘.25’.
So Thursday of last week I got my labs done just a quick E and T check. My e2 came back undectable (roche test) and my TT is 1140. Anyways what’s weird is I felt fine pretty much Wednesday - Sunday. Then all of a sudden all of this week I have felt like shit.

My doc told my I need to stop the AI for good (finally) But shouldn’t I being feeling better at this point. My last AI dose was Tuesday of last week. Also it’s odd that it took until Monday for me to start feeling the effects. Does it take awhile to get out from bottoming your E2.
 
My protocol is 60mg twice a week Monday and Thursday. I take my anastrolze on Tuesday ‘.25’.
So Thursday of last week I got my labs done just a quick E and T check. My e2 came back undectable (roche test) and my TT is 1140. Anyways what’s weird is I felt fine pretty much Wednesday - Sunday. Then all of a sudden all of this week I have felt like shit.

My doc told my I need to stop the AI for good (finally) But shouldn’t I being feeling better at this point. My last AI dose was Tuesday of last week. Also it’s odd that it took until Monday for me to start feeling the effects. Does it take awhile to get out from bottoming your E2.
yes. first day you feel nothing.. after that you feel strong anxiety in body and all other "benefits" of crashed e2 levels
 
I crashed my E2 (extreme anxiety- shut me down for 4 days or so) and it took me about 10 days for me to return to normal (low shbg guy).
 
Why the use of Anastrozole to begin with? If .25mg once per week bottomed you out there was never a need for it to begin with, in most every case.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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