D3Most hospitals will prescribe 50,000 IU of vitamin D2, not D3. So I'm wondering, which are you using D2 or D3?
D3Most hospitals will prescribe 50,000 IU of vitamin D2, not D3. So I'm wondering, which are you using D2 or D3?
The German clinicians/researchers who wrote the paper are using Dr. Coimbra's protocol to treat patients with MS. We all understand that there can be quite a lag time between what is accepted by science/medicine and what results practitioners are seeing in patients. The polymorphism theory, in essence, states that the receptors, for some reason(s), aren't sensing the vitamin D(or thyroid or testosterone), thus higher or supraphysiolgic doses are needed to overcome that cellular resistance.Are there any large controlled trials demonstrating these cures? The stuff regarding MS sounds promising, but science doesn't accept anecdotes as evidence. The cited paper also contains some hand waving and assumptions that go beyond the available evidence. As an aside, aren't receptor polymorphisms a separate issue compared to low serum levels relative to dose? Is the claim that there's insufficient 25-hydroxylation in the liver? In any case, the larger controlled trials are failing to find benefits in supplementing vitamin D, and even point to the possibility of harm at higher levels. The reality is that most people should not be concerned unless their levels naturally fall below 20 ng/mL.
Predict estradiol, DHT, and free testosterone levels based on total testosterone
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A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.
The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038