Apigenin: Estrogen Blocker?

GreenMachineX

Well-Known Member
“It was shown that high doses of apigenin (50 μM) do not display estrogen-like activity and can suppress ER activation by 17β-estradiol.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610175/

For those that haven’t seen all my posts regarding issues in my TRT, I’ve been experiencing low estrogen-like effects for almost a year, despite having even having an estrogen sensitive result of 27 about 2 months ago. 6 months ago it was measured at 7 if I recall correctly, but definitely less than 10. Could the above study be why?

About 1 month after starting a particular multivitamin, a whole slew of effects began and I’ve never quite nailed down why. I started it in 2016 in November or December and beginning of February my first dizzy spell and heart rate/palpitation/chest flutter craziness began.

Anyone have any thoughts?

FWIW, I’ve stopped absolutely every supplement as of 48 hours ago in an attempt that maybe it is anything I’m taking.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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