Any fans of AIs?

S1W

Well-Known Member
Lots of people on this site seem to place a lot of emphasis on avoiding AIs. I would count myself among them at this point, just because I don't want to add another element. And I've read the horror stories about crashing E2 with high doses.

However, I'd like to hear from people that are big fans of AIs and what your dosages might be. Did you experience a very positive, before and after kind of effect when you introduced an AI? Negative side effects? Other thoughts?
 
Lots of people on this site seem to place a lot of emphasis on avoiding AIs. I would count myself among them at this point, just because I don't want to add another element. And I've read the horror stories about crashing E2 with high doses.

However, I'd like to hear from people that are big fans of AIs and what your dosages might be. Did you experience a very positive, before and after kind of effect when you introduced an AI? Negative side effects? Other thoughts?
I don't know if I'd say I'm a big fan of anastrazole, but I know for certain that I would not be having a positive experience with TRT without it. I am one of the guys that feels great when my E2 is in a specific range. I keep it in that range using anastrazole. My T dose is 50mg twice weekly and I take between 0.20and 0.25mg at the same time as my T shots.
 
In my experience, an AI is very hard to get dialed in but well worth it once in a good place. I am now using .125 of adex every 6-7 days. I think many start at too high a dose (and too frequent) and then blame the AI instead of the dose. A low dose and long interval means that I am less likely to undershoot and I can monitor the symptoms a bit better. Also the rebound affect of adex seems very real and complicates the difficulty of getting dialed in since you're dealing with an amplified roller-coaster affect. I think many would be better with exemestane which does not have that issue although I have less experience with it.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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