Anti-Obesity Pharmacotherapy for Long-Term Obesity Management

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Dr. Carolyn T. Bramante, MD, MPH presented a grand round on Anti-Obesity Pharmacotherapy for Long-Term Obesity Management. She discussed the complexity of obesity as a disease, the physiological and genetic factors affecting it, the importance of individualizing treatment, and the effectiveness of various medications. Dr. Bramante also shared a patient example of successful weight loss in preparation for a lung transplant. She emphasized the need for frequent follow-up, individualized treatment plans, and the potential for weaning off medications after reaching target weight loss goals.


Key Takeaways:
  • Dr. Bramante is an assistant professor at the University of Minnesota specializing in Obesity management and remotely delivered interventions.
  • Obesity is a complex, multifactorial disease with societal and genetic influences.
  • Prevalence of obesity varies by ethnicity and region, with a significant impact on health disparities.
  • Obesity stigma affects individuals throughout their interactions with the healthcare system.
  • Physiological responses to weight loss show hormonal changes that promote weight regain.
  • Pillars of obesity treatment include behavioral changes, reduced calorie diet, increased physical activity, stress reduction, sleep, and medication management.
  • Medications for obesity include terzapatide, liraglutide, phentermine/topiramate, and metformin, each with its own efficacy and side effect profile.
  • Avoiding weight-gain promoting medications is important, especially in patients with obesity.
  • Bariatric surgery and endoscopic treatment options are also available for severe cases of obesity.
  • Individualized treatment plans, frequent follow-up, and the potential for weaning off medications after reaching weight loss goals are essential in obesity management.
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