Adderall to lower prolactin

[PeteMitchell]

Since dopamine inhibits prolactin, wouldn't adderall (which I believe increases dopamine) have the effect of decreasing dopamine? Is my thinking correct?

I have read on a few message boards where adderall INCREASES prolactin, and my prolactin is already a tag high. Quick responses are appreciated, as I have to take the MPRE Saturday, and REALLY need to pop a few adderall tomorrow and friday.

 

[ERO]

Vitamin B6 and P-5-P are reputed to lower prolactin naturally. I have not tried either of them personally for that reason, but something to think about.

 

[Vince Carter]

Since dopamine inhibits prolactin, wouldn't adderall (which I believe increases dopamine) have the effect of decreasing dopamine? Is my thinking correct?

I have read on a few message boards where adderall INCREASES prolactin, and my prolactin is already a tag high. Quick responses are appreciated, as I have to take the MPRE Saturday, and REALLY need to pop a few adderall tomorrow and friday.

What are you trying to do...decrease Prolactin, increase Dopamine...both?

 

[PeteMitchell]

I'm looking for board members opinions/knowledge on what effect, if any, adderall has on prolactin and dopamine levels.

 

[PeteMitchell]

I'm in the middle of trying b6 now....prolactin is not dangerously high, but it is outside Nirmal range. I just need to know how adderall effects my dopamine and prolactin levels.

 

[Vince Carter]

I haven't heard it around here; Adderall

 

[Nelson Vergel]

Horm Metab Res. 1983 Sep;15(9):439-43

Prolactin lowering effect of amphetamine in normoprolactinemic subjects and in physiological and pathological hyperprolactinemia.

DeLeo V, Cella SG, Camanni F, Genazzani AR, Müller EE.

Abstract

The effect on plasma prolactin (PRL) of d-amphetamine (Amph) was studied in normo- and hyperprolactinemic subjects. In normoprolactinemic women Amph failed to lower plasma PRL levels when infused intravenously over 1 h at the dose of 7.5 mg, but induced at the dose of 15.0 mg a modest inhibition of plasma PRL (maximum PRL inhibition 20 +/- 4.5% at 45 min). Likewise, in puerperal women Amph at the dose of 7.5 mg did not decrease significantly plasma PRL levels but it was active in this respect (maximum inhibition 37 +/- 10% at 120 min) at the dose of 15.0 mg. In subjects with presumptive evidence of a PRL-secreting adenoma, Amph at either the 7.5 mg or the 15.0 mg dose failed to alter baseline PRL levels. These results indicate that Amph is a poor PRL suppressor in either normo- or hyperprolactinemic subjects. It is proposed that this may be due to the drug's ability to effect release of dopamine mainly from a non-granular pool of the amine.

 

[Nelson Vergel]

d-Amphetamine raises serum prolactin in man: Evaluations after chronic placebo, lithium and pimozide treatment

 

[PeteMitchell]

Thanks Nelson. If I read that correctly, it's saying that adderall raises prolactin. Granted, I only understand about 1/2 of what I read on those studies.

 

[Nelson Vergel]

Thanks Nelson. If I read that correctly, it's saying that adderall raises prolactin. Granted, I only understand about 1/2 of what I read on those studies.

Yes. But it has not done so in my case. But these studies were done using IV route.