Elevated Hct...

KSPhD

Member
I am on the following protocol from Defy for my low T. Been on it 12 weeks.

Test Cyp - 140 mg/wk (70 mg every 3.5 days)

HCG - 800 IU's/wk (400 IU every 3.5 days)
Anastrozole - 0.50 mg/wk (0.25 mg every 3.5 days)

Noticed my Hct was up. The nurse suggested therapeutic phlebotomy - but given the Free Test levels, isn't a reduction in Test Cyp in order? Thanks in advance for your thoughts.


 

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I am on the following protocol from Defy for my low T. Been on it 12 weeks.

Test Cyp - 140 mg/wk (70 mg every 3.5 days)

HCG - 800 IU's/wk (400 IU every 3.5 days)
Anastrozole - 0.50 mg/wk (0.25 mg every 3.5 days)

Noticed my Hct was up. The nurse suggested therapeutic phlebotomy - but given the Free Test levels, isn't a reduction in Test Cyp in order? Thanks in advance for your thoughts.



I'd certainly not adjust your dose of testosterone. There isn't a direct relationship between total testosterone injected and the rise of hematocrit. One can't assume that by dropping your weekly dose by, say, 10%, that hematocrit will fall by 2.5%. In my doctor's practice, where a lot of us are on small, daily injections, my protocol calls for 16mg every morning, some of her patients require a phlebotomy on occasion.

As for your free testosterone, it being up slightly isn't surprising given your low SHBG - a very common phenomenon. Free testosterone values are a matter of dispute. Direct, calculated...it is a devil of a number to quote with accuracy.

Congratulations on on your estradiol.

How is are you feeling?
 
Thanks for your input CoastWatcher. Overall things are better. Greater sex drive, greater strength, less anxiety. Just need to clean up the diet and up the physical activity to get my lipids under control.
 
Free T being high is good...never bad as far as I'm concerned and CW is correct, it goes hand/hand with your SHBG @ 20. You should donate a pint of blood soon, there's a nurse on that end that throws phlebotomy's scripts at-will if you're even a tenth over the lab range, don't let that get to be much of a concern, HCT is the price you pay for entry to TRT, easily managed with a blood donation.
 
Congrats, you are now a regular blood donor. Defy will work with you, and your blood letting place if needed, to get you set up with regular 56 day donations. If you don't have any disqualifying conditions your donated blood will go into the supply chain and you might get a free t-shirt and come cookies. When my HCT get up that hight I'm quite relieved to have it taken. I feel much better almost immediately.
 
Your fine up to 55 HCT then they will take you off TRT if you go over. My HCT went up to 53 and over time fell to 48. This is what happens to most everyone from what I have seen. Make sure to stay well hydrated.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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