Anastrozole Monotherapy?

There are doctors in clinical practice who, over time, have been responsible for delivering care at an extremely high (and creative level), following the evidence and patient response to devise and refine treatment protocols that are now accepted and proving their worth time after time. In addition to the aforementioned physicians, one should include Dr. Greg Lowe, a urologist who is reputed to be remarkably capable working with patients who present with erectile issues and low androgen levels; Dr. Rand McClain, in California, who is a great friend of this Forum and is highly regarded in the field of both hormone replacement and anti-aging medicine; Drs. Larry Lipshultz and Abraham Morgentaler, in Houston and Boston respectively, treat a number of our members.

At the same time, the efforts of others, such as Dr. Joel Finkelstein, an endocrinologist at Massachusetts General and the author of the above cited article on the importance of estradiol would not be considered as cutting-edge as those men mentioned above, but he produced an article that confirmed the clinical position of those at the forefront of TRT practice. At this point, it is an oft-cited publication and confirms the clinical observations and judgement of those men who are clinical stars. His work can frequently help persuade an uninformed doctor not to plunge a patient into the hell of low estradiol.

Dr. Ryuto Nakazawa is the lead author of the article that can persuade uninformed doctors across the English-speaking world that twice weekly injections of testosterone are going to prevent the abject failure seen with less frequent injections. We've sent his work out to those who aren't fortunate enough to have doctors at the level of Saya, Crisler, Shippen, Gordon, or McClain.

If one isn't fortunate to be able to consult with a luminary, those who publish can be indirect guides and helpers.
 
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There are doctors in clinical practice who, over time, have been responsible for delivering care at an extremely high (and creative level), following the evidence and patient response to devise and refine treatment protocols that are now accepted and proving their worth time after time. In addition to the aforementioned physicians, one should include Dr. Greg Lowe, a urologist who is reputed to be remarkably capable working with patients who present with erectile issues and low androgen levels; Dr. Rand McClain, in California, who is a great friend of this Forum and is highly regarded in the field of both hormone replacement and anti-aging medicine; Drs. Larry Lipshultz and Abraham Morgentaler, in Houston and Boston respectively, treat a number of our members.

At the same time, the efforts of others, such as Dr. Joel Finkelstein, an endocrinologist at Massachusetts General and the author of the above cited article on the importance of estradiol would not be considered as cutting-edge as those men mentioned above, but he produced an article that confirmed the clinical position of those at the forefront of TRT practice. At this point, it is an oft-cited publication and confirms the clinical observations and judgement of those men who are clinical stars. His work can frequently help persuade an uninformed doctor not to plunge a patient into the hell of low estradiol.

Dr. Ryuto Nakazawa is the lead author of the article that can persuade uninformed doctors across the English-speaking world that twice weekly injections of testosterone are going to lead to abject failure. We've sent his work out to those who aren't fortunate enough to have doctors at the level of Saya, Crisler, Shippen, Gordon, or McClain.

If one isn't fortunate to be able to consult with a luminary, those who publish can be indirect guides and helpers.

Thanks that's a great list and some I haven't heard of. Regarding Dr. Ryuto Nakazawa, is that the correct spelling, I haven't heard of him and can't find much on him. Also, what is meant by his article you summarize, don't many folks on this forum do twice weekly injections?
 
Thanks that's a great list and some I haven't heard of. Regarding Dr. Ryuto Nakazawa, is that the correct spelling, I haven't heard of him and can't find much on him. Also, what is meant by his article you summarize, don't many folks on this forum do twice weekly injections?

An editing error on my part - please see the revised post. You are right: twice-weekly shots (at a minimum) are preferred. Doctor Nakazawa is Japanese, I am checking the last contact I had to see if he is in North America or returned to Japan.
 
Great feedback everyone thanks. So far I'm hearing (and agree) top doctors in this field include

Dr Justin Saya
Dr John Crisler
Dr Eugene Shippen
Dr Mark Gordon
Dr Rand McClain
Dr Larry Lipshultz
Dr Abraham Morgentaler
Dr Greg Lowe
Dr Joel Finkelstein
Dr Ryuto Nakazawa

What about Dr Thomas O'Connor out of I think CT, and Dr Aaron Grossman from Chekd?
 
Great feedback everyone thanks. So far I'm hearing (and agree) top doctors in this field include

Dr Justin Saya
Dr John Crisler
Dr Eugene Shippen
Dr Mark Gordon
Dr Rand McClain
Dr Larry Lipshultz
Dr Abraham Morgentaler
Dr Greg Lowe
Dr Joel Finkelstein
Dr Ryuto Nakazawa

What about Dr Thomas O'Connor out of I think CT, and Dr Aaron Grossman from Chekd?

It would seem Dr. Nakazawa's presence in the US was a temporary appointment. He is practicing in Japan on a full-time basis according to what I could determine.
 
I've heard and read good things about Dr. Brett Osborn but no personal experience. I do have an appointment with him in next few weeks.
 
I've heard and read good things about Dr. Brett Osborn but no personal experience. I do have an appointment with him in next few weeks.

Thanks johnt!! Yes, I've heard good things about Dr Osborn as well. Would love to hear how your appointment goes. Thanks.

Revised list:

Dr Justin Saya
Dr John Crisler
Dr Eugene Shippen
Dr Mark Gordon
Dr Rand McClain
Dr Larry Lipshultz
Dr Abraham Morgentaler
Dr Greg Lowe
Dr Joel Finkelstein
Dr Brett Osborn
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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