Possible high E2??

kelj358

New Member
So..back story. Been on 50mg/2x week of test cyp for the last few month. Seems to be going fine, just been low on energy over the last 3 weeks or so. Libido has been fine, nothing crazy. Last blood draw the Dr DID NOT order E2, FT, Bio available on the draw. Obviously, he doesn't know TRT very well. I'm learning too. He does seem amenable to do what I ask, so this forum has been very helpful. TT was at 800 tested at trough. So all good..im sure its higher at peek...maybe 1200?

My question is, is fatigue a noticeable side effect of high E2? Previously my E2 was at 39 and my TT was hitting 531 at trough. So, I can only guess since on my new protocol with the increase in TT and presumably FT and E2 (again, last draw did not include these numbers) maybe my E2 is way up? I'd assume another panel would be need for a definitive answer. Anyway, just looking for a little guidance on possible solutions. Would I be out of line to maybe drop to 40mg 2x week?
 
So..back story. Been on 50mg/2x week of test cyp for the last few month. Seems to be going fine, just been low on energy over the last 3 weeks or so. Libido has been fine, nothing crazy. Last blood draw the Dr DID NOT order E2, FT, Bio available on the draw. Obviously, he doesn't know TRT very well. I'm learning too. He does seem amenable to do what I ask, so this forum has been very helpful. TT was at 800 tested at trough. So all good..im sure its higher at peek...maybe 1200?

My question is, is fatigue a noticeable side effect of high E2? Previously my E2 was at 39 and my TT was hitting 531 at trough. So, I can only guess since on my new protocol with the increase in TT and presumably FT and E2 (again, last draw did not include these numbers) maybe my E2 is way up? I'd assume another panel would be need for a definitive answer. Anyway, just looking for a little guidance on possible solutions. Would I be out of line to maybe drop to 40mg 2x week?

Would not blame your fatigue on elevated E2 as you have no clue where it sits let alone numerous things can cause you too feel run down, lack of quality sleep/OSA, low ferritin/iron, excess stress (physical/mental), high blood pressure tonnage a few.

Always need to know where your critical blood markers RBCs, hemoglobin and hematocrit sit on said protocol (dose of T/injection frequency).

Throw ferritin/iron in there too especially if you get caught up on that donating too frequently merry go round.

Again you are missing the most critical blood marker your trough FT.

All we know here is you are hitting a high-end trough TT 800 ng/dL 84 hrs post-injection.

Your SHBG sat at 31 nmol/L (normal) tested back in July when you were injecting 100 mg T once weekly which had you hitting a trough TT 531 ng/dL 7 days post-injection.

Again if you knew where your SHBG sat of know we could easily calculate your trough FT.

Before jumping the gun here you need to know where your trough FT and estradiol sit.

Would not even consider lowering your dose especially if you are hitting a healthy trough FT within reason.

As I stated in your previous thread just pay out of pocket and use Nelson's discounted labs.

Forget BAT all you need here is TT, FT and estradiol.

Could thrown in SHBG too!












 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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