Possible high E2??

kelj358

New Member
So..back story. Been on 50mg/2x week of test cyp for the last few month. Seems to be going fine, just been low on energy over the last 3 weeks or so. Libido has been fine, nothing crazy. Last blood draw the Dr DID NOT order E2, FT, Bio available on the draw. Obviously, he doesn't know TRT very well. I'm learning too. He does seem amenable to do what I ask, so this forum has been very helpful. TT was at 800 tested at trough. So all good..im sure its higher at peek...maybe 1200?

My question is, is fatigue a noticeable side effect of high E2? Previously my E2 was at 39 and my TT was hitting 531 at trough. So, I can only guess since on my new protocol with the increase in TT and presumably FT and E2 (again, last draw did not include these numbers) maybe my E2 is way up? I'd assume another panel would be need for a definitive answer. Anyway, just looking for a little guidance on possible solutions. Would I be out of line to maybe drop to 40mg 2x week?
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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