Can receptors being overwhelmed doing TRT be the reason Libido disappeared?

[HarryCat]

When you talk about a swing in T levels do you mean like a surge or like highs and lows?

It's interesting to me because i've heard that propionate esters mimic the bodys natural production more, and everyone seems to be all about keeping blood levels stable with more frequent injections but maybe thats the problem ?

In his book, Dr. Crisler has this to say:
"Often they will tell you they felt “incredible” the first couple of weeks (and bursting with libido), but they don’t feel quite as good now. This is because subjective findings are the best while serum androgen levels are accelerating. Adjunctive to this phenomenon is the fact their HPTA was not yet suppressed, so their endogenous production was higher than it would be by the end of the month, and there is a burst of dopamine playing to upregulated dopamine receptors in the first days as well. TRT patients are always HPTA-suppressed to greater or lesser degree. And Bioavailable Estrogen may not have risen yet, so same is not masking the benefits of the testosterone supplementation."

and:
"By the way, this is why testosterone troches are sometimes of great benefit, as they quickly accelerate serum androgen levels"

and:
"That is because TD’s (transdermals) produce a serum androgen profile which varies greatly throughout the day, as it does normally in an otherwise young, strong, healthy male. It would appear that entropy (randomness) in hormone levels are part and parcel of the process of youth."

And yet when you spend time on forums like this one the vast majority of guys will tell you that frequent test cyp injections are the way to go because it flat lines your T level and therefore reduces the conversion to E2. And Dr. Crisler himself uses shots.

I guess, in the end, everyone is different and all you can do is try different protocols until you find one that works.

 

[ERO]

Dr Crisler is talking about the normal daily swings - not swings of a week or of several days. Guys with normal T production have the highest T in the early morning and the level tapers lower the rest of the day into evening and then starts over.

 

[HarryCat]

Dr Crisler is talking about the normal daily swings - not swings of a week or of several days. Guys with normal T production have the highest T in the early morning and the level tapers lower the rest of the day into evening and then starts over.

True, but my doc has said he has seen benefit in some patients on TD's who take a day or two off each week. So this is adding a weekly variation on top of the daily variation.