AI of Choice

[JWSimpkins]

For those of you on an aromatase inhibitor (AI), what is your drug of choice, and why?

1. Letrozole

2. Anastrozole

3. Aromasin

 

[Gene Devine]

Before I went on twice weekly injections and serum levels stabilized and didn't need an AI anymore the one of choice for me is Anastrozole.

Just a good proven AI with little sides, good half life and easy to get.

 

[Nelson Vergel]

None if you can avoid them

 

[JWSimpkins]

Yes, I would like to avoid an AI if at all possible, so I'm doing twice weekly shots (Mon & Thurs), as well as using natural supplements (zinc, LEF Super Miraforte). Next BW mid-November, so then I'll know one way or another!

 

[Gene Devine]

Yes, I would like to avoid an AI if at all possible, so I'm doing twice weekly shots (Mon & Thurs), as well as using natural supplements (zinc, LEF Super Miraforte). Next BW mid-November, so then I'll know one way or another!

If the twice weekly doesn't work for you JW check out the info in here on SC injections...this has worked for many men as well!

There's a good thread running in here on that with commentary from both Drs. Crisler and Saya.

 

[Keith Willse]

I personally do not like Irreversible steroidal inhibitors (Aromasin) and would never use them. When required and all other options have been exhausted. My AI of choice is Anastrozole in the lowest possible dose. For example .1 twice a week.

 

[JWSimpkins]

If the twice weekly doesn't work for you JW check out the info in here on SC injections...this has worked for many men as well!

There's a good thread running in here on that with commentary from both Drs. Crisler and Saya.

Yeah Gene, I tried doing SC daily injection of 15mg, but I just couldn't keep sticking myself everyday.

 

[JWSimpkins]

I personally do not like Irreversible steroidal inhibitors (Aromasin) and would never use them. When required and all other options have been exhausted. My AI of choice is Anastrozole in the lowest possible dose. For example .1 twice a week.

Keith, do you mean .10mg twice a week?

 

[Gene Devine]

Yeah Gene, I tried doing SC daily injection of 15mg, but I just couldn't keep sticking myself everyday.

No need to inject every day JW. You can inject SQ twice weekly if you really wanted and still get the subjective benefits.

Most of the Doc's I know like SQ E3D.

 

[JWSimpkins]

No need to inject every day JW. You can inject SQ twice weekly if you really wanted and still get the subjective benefits.

Most of the Doc's I know like SQ E3D.

How would twice weekly SC reduce aromatization anymore than IM twice weekly?

 

[Gene Devine]

How would twice weekly SC reduce aromatization anymore than IM twice weekly?

The ester is cleaved at a slower rate than IM...or that's what some practitioners believe in their assessment of men who go this injection route.

 

[robs2nd75]

I personally do not like Irreversible steroidal inhibitors (Aromasin) and would never use them. When required and all other options have been exhausted. My AI of choice is Anastrozole in the lowest possible dose. For example .1 twice a week.

Keith, how do you chop Anastrozole into such small pieces?

 

[Austinite]

No prescriptions for me anymore (finally). DIM/Zinc/Copper does the job.

 

[JWSimpkins]

No prescriptions for me anymore (finally). DIM/Zinc/Copper does the job.

Is it possible to go on an AI and then through diet and exercise, drop body fat low enough as to minimize aromatization, therefore allowing the AI to be dropped?

 

[Austinite]

Is it possible to go on an AI and then through diet and exercise, drop body fat low enough as to minimize aromatization, therefore allowing the AI to be dropped?

Sure thing. I personally believe that it should be a goal, for everyone to rid themselves from prescription AI's; or minimize use as much as possible. Of course, this is individualistic. In my case, switching from intramuscular to subQ injections, dropping my cyp dose from 125 to 100mg weekly had me hovering just over range on a sensitive e2 scale. Adding DIM/zinc/copper brought be down to a healthy range.

It was worth it, even at the expense of going from 800 ng/dL to ~ 700. I still feel great without the additional cost. Dropping my Bodyfat most certainly had a role as well.

 

[JWSimpkins]

Cool, thanks for all of the advice guys! I'm going to wait to see what my BW results are, and if my E2 is still high I will probably start arimidex and then work on lowering my body fat to singe digits, so I can eventually wean myself off.

 

[Gene Devine]

Sure thing. I personally believe that it should be a goal, for everyone to rid themselves from prescription AI's; or minimize use as much as possible. Of course, this is individualistic. In my case, switching from intramuscular to subQ injections, dropping my cyp dose from 125 to 100mg weekly had me hovering just over range on a sensitive e2 scale. Adding DIM/zinc/copper brought be down to a healthy range.

It was worth it, even at the expense of going from 800 ng/dL to ~ 700. I still feel great without the additional cost. Dropping my Bodyfat most certainly had a role as well.

^^^^That's a great plan Austin!

 

[Keith Willse]

@JWSimpkins, Yes I mean a 10th of the standard 1mg dose.

@robs2nd75, I get them compound that when in a troche I could never split a 1mg tab that small.

 

[Dr.V.P.C.]

My problem is that my patients always say :
"what ? no anastrozole ? " or " what ? only this os anastrozole? , i don´t want to have gyno... my fitness instructor said i need at least 0.5mg of anastrozole daily "
Damn expert fallacy !
And i always explain...low estrogen is as bad as high estrogen...and bla bla bla.... but this is a terrible fallacy that AI is always needed. Very hard to deal with.

 

[Austinite]

My problem is that my patients always say :
"what ? no anastrozole ? " or " what ? only this os anastrozole? , i don´t want to have gyno... my fitness instructor said i need at least 0.5mg of anastrozole daily "
Damn expert fallacy !
And i always explain...low estrogen is as bad as high estrogen...and bla bla bla.... but this is a terrible fallacy that AI is always needed. Very hard to deal with.

Funny. It can't be easy teaching folks that "Less is more" in most cases.