AI Monotherapy

[MikeXL]

I have used the search feature but cannot seem to find anything.

Has anyone used an aromatase inhibitor as monotherapy for TRT? If so, how was your experience?

We obviously are familiar with Clomid as therapy. MY understanding as to how that works is that the clomid hides estrogen from the hypothalamus so that the hypothalamus releases GNRH, which gets the ball rolling in the HPTA. Well why would an AI lowering estrogen to the degree that clomid hides estrogen do the same thing? Of course this would all be contingent on not lowering E2 to an appropriate degree.

Any thoughts are welcome?

 

[Weasel]

I believe this is a legit option and not sure why it is not used more often.

My only thought as to why it isnt more popular is that it actually will reduce estrogen, which is vital for bone health as well as other organs.

 

[CoastWatcher]

The steroid boards discuss it. What's the state of your axis at this point? And your current prior history of TRT?

 

[Ardoc]

i did try it for a few months before starting on Test cyp (I used Arimidex). Although my TT rose into the lower part of the reference range i felt no difference at first and then started to feel worse. I did not know a lot about TRT or have my current MD at that point and so didn't have tests for FT or E2. I suspect it really crashed my E2. IMHO the only way this would make sense is if you had very high E2 so that blocking the conversion from T, lowered your E2 into proper range while at the same time increasing your T into a reasonable range. In any other situation I believe you would just drive your E2 to zero and feel worse not better.

 

[Vince]

I've only heard of it being used once, when someone was not on TRT. As you stated the problem would be lowering your E2 too low.

 

[MikeXL]

I am on TRT. But this is about a relative who is not and who has high E2

The steroid boards discuss it. What's the state of your axis at this point? And your current prior history of TRT?