Progesterone Dose for Men

[Cataceous]

As far as lab timing goes, u would inject at night before bed and then get labs done first thing in the morning?

Yes, which probably means levels are a bit higher overnight.

 

[Gman86]

it’s going well so far, I have noticed androgenic results from it and increased socialization. I’m calling people, checking on people, making plans. I’d say that I get this desire to touch/progress things with women I interact with. I have low libido but interaction with women increases it.

I’m taking .6mg.



progesterone is substrate for cortisol however it also lowers cortisol in serum maybe indicating that it increases metabolism of cortisol.

it is also possible that the temp Increase from thyroid hormone for many is due to its enhancement of steroids like progesterone. Progesterone possibly may directly raise body temperature despite lowering cortisol. Maybe it lowering cortisol allows for better thyroid hormone output.

I’m confused as it seams as though things work in both direction. Correcting thyroid improves hormones. Correcting hormones can improve thyroid. Everything is tightly knit.

I believe @Charliebizz said that progesterone raised his serum cortisol level to the top of the range. So for him it raised his cortisol levels quite a bit, not lowered them

 

[Gman86]

it’s going well so far, I have noticed androgenic results from it and increased socialization. I’m calling people, checking on people, making plans. I’d say that I get this desire to touch/progress things with women I interact with. I have low libido but interaction with women increases it.

I’m taking .6mg.



progesterone is substrate for cortisol however it also lowers cortisol in serum maybe indicating that it increases metabolism of cortisol.

it is also possible that the temp Increase from thyroid hormone for many is due to its enhancement of steroids like progesterone. Progesterone possibly may directly raise body temperature despite lowering cortisol. Maybe it lowering cortisol allows for better thyroid hormone output.

I’m confused as it seams as though things work in both direction. Correcting thyroid improves hormones. Correcting hormones can improve thyroid. Everything is tightly knit.

So ur only injecting 0.6mg subQ once right before bed each day? What made u go down to 0.6mg? Did u just want to try and find the minimal effective dose that would maintain the positive benefits that ur getting?

 

[Gman86]

@JA Battle What ur experiencing so far seems pretty life changing. Would u say that progesterone seems to be the missing puzzle piece of ur protocol based off of the results u’ve gotten so far?

 

[gerardo]

I did start injections with 2.5 mg per day, about four times my current dose. And it did result in about four times the serum level. But it was only a few days before I measured this result and titrated down. It wasn't long enough to separate out any benefits from possible honeymoon effects. I do recall being in a particularly good mood for a couple weeks around there. I don't think I'd experiment with higher doses again unless I found out that where I am is lower than average for young men.

Only 2.5 mg per day. With this dosage, did you still suppress the hpg axis?

 

[JA Battle]

@JA Battle What ur experiencing so far seems pretty life changing. Would u say that progesterone seems to be the missing puzzle piece of ur protocol based off of the results u’ve gotten so far?

thats interesting that happened to Charlie. It makes sense though as progesterone is upstream of cortisol. I’m unsure of his dose and protocol.

However, progesterone is also linked to lowering cortisol levels but perhaps it is a u shaped curve just like progesterones effects on the gaba receptor.

pregnenolone has similar u shaped curve on cortisol and the gaba receptor so maybe it is due to its conversion to progesterone.

dhea also has effects on cortisol.

I inject 1.2mg. .6mg in the morning in my morning multi hormone shot that is .26ml. Since this is a decent size intramuscular shot I am hoping that it slows down the absorption and creates a slow release. Theoretically it should as larger oil depots takes a period of time to absorb. The other .6mg I do subq at bet time.

mom not convinced in the new progesterone range. It is a sudden large change in the range and I’m not confident that our levels should be that low. I’m using the old reference range for now and targeting the 1.0 ng/ml range. Twice daily admin also ensures I have more stable levels.

i am also becoming more interested in TBG (thyroid binding globulin) I believe we should be testing this just as we test shbg.

as far as life changing, I’d say it is definitely a nice enhancement in a few areas I’m lacking although it is just one piece. I’m still working to dial in my e2 and dht also and will begin with dhea and possibly pregnenolone soon. All injected. Every piece is equally important and I’m still a ways out but I do enjoy the incremental improvements

 

[Charliebizz]

thats interesting that happened to Charlie. It makes sense though as progesterone is upstream of cortisol. I’m unsure of his dose and protocol.

However, progesterone is also linked to lowering cortisol levels but perhaps it is a u shaped curve just like progesterones effects on the gaba receptor.

pregnenolone has similar u shaped curve on cortisol and the gaba receptor so maybe it is due to its conversion to progesterone.

dhea also has effects on cortisol.

I inject 1.2mg. .6mg in the morning in my morning multi hormone shot that is .26ml. Since this is a decent size intramuscular shot I am hoping that it slows down the absorption and creates a slow release. Theoretically it should as larger oil depots takes a period of time to absorb. The other .6mg I do subq at bet time.

mom not convinced in the new progesterone range. It is a sudden large change in the range and I’m not confident that our levels should be that low. I’m using the old reference range for now and targeting the 1.0 ng/ml range. Twice daily admin also ensures I have more stable levels.

i am also becoming more interested in TBG (thyroid binding globulin) I believe we should be testing this just as we test shbg.

as far as life changing, I’d say it is definitely a nice enhancement in a few areas I’m lacking although it is just one piece. I’m still working to dial in my e2 and dht also and will begin with dhea and possibly pregnenolone soon. All injected. Every piece is equally important and I’m still a ways out but I do enjoy the incremental improvements

At that time I was on prog only 20 mg topical. On blood test it raised my am cortisol from 12 to about 18. On 4x saliva test wasn't much of a change so not sure how significant those results were. I also notice a mental lift from prog. I might add.it back into my trt but kind of want to give ldn a try first not to add to many variables

 

[Cataceous]

Only 2.5 mg per day. With this dosage, did you still suppress the hpg axis?

This thread is about progesterone, probably used in conjunction with TRT. I'm not sure how suppressive it is in natural men.

 

[Gianluca]

50mg Pregnenolone capsule, raised my Progesterone from .1 to .7, (Labcorp scale) I also use a 5mg Progesterone capsule, which seem to have a mild sedating effect, I think it improves my sleep and skin

 

[Gman86]

50mg Pregnenolone capsule, raised my Progesterone from .1 to .7, (Labcorp scale) I also use a 5mg Progesterone capsule, which seem to have a mild sedating effect, I think it improves my sleep and skin

Were u using the 5mg of progesterone when ur progesterone level went from .1 to .7, or were u just using 50mg of Pregnenolone?

 

[Gman86]

thats interesting that happened to Charlie. It makes sense though as progesterone is upstream of cortisol. I’m unsure of his dose and protocol.

However, progesterone is also linked to lowering cortisol levels but perhaps it is a u shaped curve just like progesterones effects on the gaba receptor.

pregnenolone has similar u shaped curve on cortisol and the gaba receptor so maybe it is due to its conversion to progesterone.

dhea also has effects on cortisol.

I inject 1.2mg. .6mg in the morning in my morning multi hormone shot that is .26ml. Since this is a decent size intramuscular shot I am hoping that it slows down the absorption and creates a slow release. Theoretically it should as larger oil depots takes a period of time to absorb. The other .6mg I do subq at bet time.

mom not convinced in the new progesterone range. It is a sudden large change in the range and I’m not confident that our levels should be that low. I’m using the old reference range for now and targeting the 1.0 ng/ml range. Twice daily admin also ensures I have more stable levels.

i am also becoming more interested in TBG (thyroid binding globulin) I believe we should be testing this just as we test shbg.

as far as life changing, I’d say it is definitely a nice enhancement in a few areas I’m lacking although it is just one piece. I’m still working to dial in my e2 and dht also and will begin with dhea and possibly pregnenolone soon. All injected. Every piece is equally important and I’m still a ways out but I do enjoy the incremental improvements

What effect does DHEA have on cortisol? It has an inverse relationship, correct? So the higher a person’s DHEA the lower the cortisol? That’s my understanding, is that wrong or correct from what u know?

When u say dial in E2 and DHT, are u trying to lower E2 and raise DHT? What symptoms are u still looking to improve?

 

[JA Battle]

What effect does DHEA have on cortisol? It has an inverse relationship, correct? So the higher a person’s DHEA the lower the cortisol? That’s my understanding, is that wrong or correct from what u know?

When u say dial in E2 and DHT, are u trying to lower E2 and raise DHT? What symptoms are u still looking to improve?

i believe it is largely an inverse relationship. However, it may also follow a u shaped curve or be dependent on other parameters as well. I’d need to examine this further as I cannot remember/ did not get deep enough into reading about this matter.

I believe hormones can affect people differently based on their other hormones. Hormones even compete with each other. So saying dhea lowers cortisol for everybody, regardless of where they sit on the range, is wrong. Correcting low to mid range dhea may actually raise cortisol for certain individuals. The intertwining of feedback mechanisms in this realm of hormones is astounding

I’m trying to raise e2 from around 15 to 35 and then will reevaluate. I’m injecting .042 mg of estradiol valerate (uncommon esterIn serum, my estradiol is anywhere from 1/3 to 1/2 of what it should be based on my testosterone level fluctuating in between 700-1000ng/dL.

I am also working to raise dht from 48 ng/dL to 80ish for starters and then will evaluate. I’m injecting .4mg of dht valerate.

I’m going in for bloodwork soon to see where these levels sit and will adjust dose til I get there.

symptoms I’m currently facing are fluctuating professional drive, energy and athletic output, and sometimes mood slightly. Sexually I’d say I’m on the lower end of functioning. I want a higher sexual drive/confidence. Also erectile quality fluctuates.

I’d say the sexual symptoms are the primary ones. If I locked down a steady partner I’m sure it is an issue that would disappear, however, I’m subconsciously worried about performing with new partners. I also don’t want distraction from my duties as a dad of 4 and also my professional duties. I need to profit 8k per month to stay afloat so I have just removed the idea of women from my life. Which is not ok.

the other symptoms I mentioned really started to come about after quitting nicotine use 2 months ago. My hdl and triglycerides improved from quitting but now all of these symptoms have come about. I’m assuming it’s from it increasing my rt3 to 20. I’m not certain it increases it because I don’t have pre-quitting rt3 test. Nonetheless last I check it’s at 20. I tried t3 but decided to hold off until I have these other hormones dialed. Maybe that was a mistake. After typing this I’m actually deciding to order some more t3.

Another interesting thing I read, estradiol increases thyroid hormones but it also increases thyroid binding globulin.

 

[Gman86]

i believe it is largely an inverse relationship. However, it may also follow a u shaped curve or be dependent on other parameters as well. I’d need to examine this further as I cannot remember/ did not get deep enough into reading about this matter.

I believe hormones can affect people differently based on their other hormones. Hormones even compete with each other. So saying dhea lowers cortisol for everybody, regardless of where they sit on the range, is wrong. Correcting low to mid range dhea may actually raise cortisol for certain individuals. The intertwining of feedback mechanisms in this realm of hormones is astounding

I’m trying to raise e2 from around 15 to 35 and then will reevaluate. I’m injecting .042 mg of estradiol valerate (uncommon esterIn serum, my estradiol is anywhere from 1/3 to 1/2 of what it should be based on my testosterone level fluctuating in between 700-1000ng/dL.

I am also working to raise dht from 48 ng/dL to 80ish for starters and then will evaluate. I’m injecting .4mg of dht valerate.

I’m going in for bloodwork soon to see where these levels sit and will adjust dose til I get there.

symptoms I’m currently facing are fluctuating professional drive, energy and athletic output, and sometimes mood slightly. Sexually I’d say I’m on the lower end of functioning. I want a higher sexual drive/confidence. Also erectile quality fluctuates.

I’d say the sexual symptoms are the primary ones. If I locked down a steady partner I’m sure it is an issue that would disappear, however, I’m subconsciously worried about performing with new partners. I also don’t want distraction from my duties as a dad of 4 and also my professional duties. I need to profit 8k per month to stay afloat so I have just removed the idea of women from my life. Which is not ok.

the other symptoms I mentioned really started to come about after quitting nicotine use 2 months ago. My hdl and triglycerides improved from quitting but now all of these symptoms have come about. I’m assuming it’s from it increasing my rt3 to 20. I’m not certain it increases it because I don’t have pre-quitting rt3 test. Nonetheless last I check it’s at 20. I tried t3 but decided to hold off until I have these other hormones dialed. Maybe that was a mistake. After typing this I’m actually deciding to order some more t3.

Another interesting thing I read, estradiol increases thyroid hormones but it also increases thyroid binding globulin.

If ur trying to raise dht and E2 why don’t u just raise ur test dose. I personally need my total T at least 1600+ to get my free T to where I feel good

Whats ur free T and SHBG levels?

I would say a small dose of T3, to lower ur RT3 at least into the single digits, wouldn’t be a bad idea. Do u know if taking T3 is suppressive at all? I’ve heard conflicting opinions. Curious if it just adds onto ur existing free T3, or if it suppresses ur endogenous thyroid production and a small dose of T3 will lower free T3, like taking too small of a dose of testosterone would do. What are ur thoughts?

 

[JA Battle]

If ur trying to raise dht and E2 why don’t u just raise ur test dose. I personally need my total T at least 1600+ to get my free T to where I feel good

Whats ur free T and SHBG levels?

I would say a small dose of T3, to lower ur RT3 at least into the single digits, wouldn’t be a bad idea. Do u know if taking T3 is suppressive at all? I’ve heard conflicting opinions. Curious if it just adds onto ur existing free T3, or if it suppresses ur endogenous thyroid production and a small dose of T3 will lower free T3, like taking too small of a dose of testosterone would do. What are ur thoughts?

For one thing I don’t think it’s been proven yet that raising t to 1200+ is inherently bad as long as care is taken to ensure other metabolic parameters are stable and in range.

I am personally a bit ocd. When I found out I have the power to independently control these metabolites more concisely while maintaining physiologic testoerone levels then for me it was a no brainer. Especially with increasing my test dose, the rate at which I convert t to e2 is so low that with adding testosterone it just makes the situation worse symptomatically. I have high hopes for this approach. I have the ultimate control.

If my body is not making enough testosterone, then why should I trust it to make proper use of the testosterone that I give it.

I haven’t recently tested my free t but my shbg is always 30-40.

yes, I’m likely to add back t3. I was thinking that possibly raising my dht would help the t4-t3 conversion as most androgens do. I will be evaluating this soon after I get my dht and e2 numbers within the next 2 weeks.
I think a little t3 5-10mcg daily is not a bad idea for most people, especially in times of stress.

I’m also thinking of medicinally using nicotine as it is a powerful metabolic agent and before I quit I was literally able to work 80+ hours per week and loving life. I quit and then shortly after found my couch more and more frequently.

today I bought a vape to use nicotine. I feel like my brain is awake again. I’m sure I can combat some of the consequences of the nicotine’s effects on my hdl by making sure that I follow through with dialing my e2 up a bit as e2 will raise my hdl.

 

[Gianluca]

Were u using the 5mg of progesterone when ur progesterone level went from .1 to .7, or were u just using 50mg of Pregnenolone?

only Pregnenolone, 5mg oral Progesterone increase my Progesterone serum of .1 only

 

[DixieWrecked]

I love pregnenolone. Haven't had my progesterone tested but I know I like how it feels. DHEA neve made me feel very good. Kinda grumpy or moody.

 

[Goel]

I’m also thinking of medicinally using nicotine as it is a powerful metabolic agent and before I quit I was literally able to work 80+ hours per week and loving life. I quit and then shortly after found my couch more and more frequently.

today I bought a vape to use nicotine. I feel like my brain is awake again. I’m sure I can combat some of the consequences of the nicotine’s effects on my hdl by making sure that I follow through with dialing my e2 up a bit as e2 will raise my hdl.

Funny you should post that as I've considered nicotine via either gum or patches

 

[Gman86]

I love pregnenolone. Haven't had my progesterone tested but I know I like how it feels. DHEA neve made me feel very good. Kinda grumpy or moody.

What’s ur dose again? U take it at night? What form do u take? Just started taking 5mg of oral compounded quick release before bed last night

 

[Gianluca]

What’s ur dose again? U take it at night? What form do u take? Just started taking 5mg of oral compounded quick release before bed last night

how did it go? for some reason I notice if I take it with dinner works better than later before bed

 

[Gman86]

how did it go? for some reason I notice if I take it with dinner works better than later before bed

Works better in what way(s)?

So far it’s going fine. 5mg is a super low dose, so probably don’t notice much bad or good. Slept fine, and feel about the same today. If I don’t notice any differences after a week I’ll bump it up to 10mg, either in the evening or before bed. Curious why it works better for u taking it in the evening