When I was on HCG mono, E2 was around 60, and nipples were so sensitive and itchy that I would scratch them until they would bleed. Eventually grew a small lump under my left nipple. Upped my dose of anastrozole and luckily the lump went away, and the itchiness lessened a little. I ended up going off of HCG mono due to not being able to control the nipple sensitivity.
Fast forward to being on TRT now, I’ve had E2 as high as 70, with zero nipple sensitivity or itchiness.
I never had prolactin tested back when I was on HCG mono, but it’s been in the normal range while on TRT. So my guess is, that HCG was raising my prolactin too much. I think prolactin was the culprit, in regards to my nipple and gyno issues.
So I would personally make sure your prolactin isn’t too high.