Vince, thank you very much for explaining this, I really appreciate it, this is definitely something new I need to consider, you know when my E2 LC/MS/MS goes over 40/50 I really start feeling "crazy" meaning more emotional, anxiety, bloated reddish face and I develop some type of sexual addiction, like it is always my mind in a crazy way......I wonder where actually. according to this theory, my FE would be....very interesting, I may want to try to up my AI and see how I feel
Per one of Dr Crisler's recent books the thought that with low SHBG as you know means there's more T that is unbound and is able to be used by the body, typically us guys see Free T that is way above lab ranges, over 3% of total. The thought goes that along with the Free T, there is Free Estrogen for the same reason...low SHBG. AS the theory goes the Free E results in the idea that low SHBG guys may need to be in the teens with LC/MS/MS testing because the amount of Free Estrogens. This is opposed to the standard thought of ~21-30 for E2. It's a very new idea this Free Estrogens and SHBG.