Interesting - wouldn't high SHBG mean less frequent injections, from what I've read in here?I am high SHBG, best with E3.5D for me. Like everything with Hormones, it is highly individual. Starting with twice a week is common. You will have to test it out for yourself.
My SHBG runs in the 50's and I inject 80 mg every 3.5 days, 420 IU of HCG M W F and 25 mg DHEA twice a day. I have been on TRT for 15 months and am still making small tweaks to my dose but I am close to my ideal regimen now. It has taken several iterations of making a small change to one thing, waiting 2 months, drawing labs and repeating. With the high SHBG I need to run a total T around 1200 to keep my free T where I feel my best - mid 20's. This is a regimen that everyone would warn against because it screams HIGH ESTROGEN but the high SHBG guards against that. My E2 runs consistently around 50 but my free E2 is dead normal and I have no E2 symptoms.