The Case Against Antidepressants

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Fortunate

Well-Known Member
This article describes my experience thus far:


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Good thing I listened to my Doctor. Now I can enjoy destroying the gym once again and QOL has improved significantly. Knock on wood it has only been a few months.

@Fortunate, @Belekas, @bixt and others who have wondered about TRT/TOT and exaggerated autonomic/inotropic/chronotropic effects...5 mg/day of escitalopram has me handling upping my "TRT" dose from 80 to 100 to 120 mg/week TC/TP mix much better than prior to its use. Probably another thing to watch out for as it may provide a cover to allow some of us sensitive folk to up our dose (more than we need for TRT) for ahem "hobby" purposes.

And full disclosure I am probably just late to the party from years ago about the touted low dose SSRI + TOT mix. Thanks for your patience @FunkOdyssey. It is nice to learn at the knees from someone with so much field experience.

The SSRI did nothing for my depression though which is pretty funny (no primary effect). Maybe made it a little worse. Good thing I learned how to cope with that years ago, and it allows me to lift and enjoy body dysmorphia (which helps with the depression - secondary vs primary effect).


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This is interesting. I have been oddly, tolerating a slightly higher dose of enanthate than usual. Not sure why, but I have some theories. After I watch things a little while longer, I’ll post an update. Very glad you are making progress.
 
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Fortunate

Well-Known Member
Ma

May not do much/anything for depression but sure as sh*t (complex scientific term) works on sympathetic regulation. Vast improvement in this chronic exerciser. Not even close as compared to exercise. But I have made the deal with Satan as my mood and anhedonia have gotten worse. Probably good time to add back in some nandrolone, oxandrolone and stanozolol!

And no one has commented on Rollins' masterpiece. I am disappointed in you all.
Love Henry Rollins. Actually, every time I look at @madman’s avatar, I think of him. I think maybe it’s Henry Rollins in disguise lurking among us!
 

readalot

Member
4 month SSRI update:
Holding steady at 120 mg/week TC/TP blend (4:1). Escitalopram working like a champ with the anxiety and panic. Depression and anhedonia the same. Debating next ramp up on the Test but Hct already at 48-50% on last blood draw.
 
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DS3

Well-Known Member
This is consistent with the idea that something about excessively high or excessively stable levels of T and related hormones is numbing or depressing. The forms of TRT most likely to avoid these symptoms IMO are:

  • Low/moderate doses of cypionate or enanthate injected once weekly
  • Low/moderate doses of cream. Once daily application might be preferable to twice daily.
  • Low/moderate doses of propionate injected ED or EOD
  • Jatenzo and similar orals
  • Natesto
I’m not sure how else to say it, but this bit of experiential knowledge goes hard. Rock on
 

readalot

Member
I would not change a thing
That would be a thoughtful approach by a wise man. Gainz greed is a powerful master that torments constantly and patiently.


I used to do a little but a little wouldn't do it
So the little got more and more
I just keep tryna get a little better
Said the little better than before
I used to do a little but a little wouldn't do it
So the little got more and more
I just keep tryna get a little better
Said the little better than before

Stuck it in the middle and I shot it in the middle
And it, it drove outta my mind
I should've known better, said I wish I never met her
Said I leave it all–behind
Yowsa!

 
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readalot

Member

Overall I am still net positive but make sure you understand going in the risk vs reward. For someone with many years of experience with emotional blunting it is a tradeoff I am making.
 

readalot

Member
Dropped this week to 2.5 mg/day escitalopram. 10 mg/day seemed to make depression worse. Will try to titrate down to lowest dose and hold on to whatever panic/anxiety improvement I can.

Recent article:



Very nice MM Kinetic workup for a number of ADs:


Example:
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1675178325955.png


Lots of room to titrate down from typical 10 mg/day. Dial in your brain alteration as you like.




1675178505618.png



Very nice discussion. You should read it. You may learn alot.

1675178664380.png
 
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