Telmisartan experiences/ info

[Biobro]

Couple interesting studies of telmi.
Would be curious if anyone have access to see full study of those:?
@madman?

Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials - PubMed

The findings suggest that telmisartan affected fat distribution, inducing visceral fat reduction, and thus could be useful in hypertensive patients with obesity/overweight, metabolic syndrome, or glucose intolerance.

pubmed.ncbi.nlm.nih.gov

Effects of telmisartan on fat distribution in individuals with the metabolic syndrome - PubMed

The results imply that telmisartan could treat both the hemodynamic and metabolic aberrations seen in patients with the metabolic syndrome, improving insulin resistance and glucose intolerance at least partly through visceral fat remodeling.

pubmed.ncbi.nlm.nih.gov

 

[madman]

Couple interesting studies of telmi.
Would be curious if anyone have access to see full study of those:?
@madman?

Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials - PubMed

The findings suggest that telmisartan affected fat distribution, inducing visceral fat reduction, and thus could be useful in hypertensive patients with obesity/overweight, metabolic syndrome, or glucose intolerance.

pubmed.ncbi.nlm.nih.gov

Effects of telmisartan on fat distribution in individuals with the metabolic syndrome - PubMed

The results imply that telmisartan could treat both the hemodynamic and metabolic aberrations seen in patients with the metabolic syndrome, improving insulin resistance and glucose intolerance at least partly through visceral fat remodeling.

pubmed.ncbi.nlm.nih.gov

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[Biobro]

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Brilliant, Thanks madman!

 

[BigTex]

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Thanks Madman! I was just about to request these. I have seen the abstracts before.

 

[Biobro]

Thanks Madman! I was just about to request these. I have seen the abstracts before.

Interesting one too:

Telmisartan reduced abdominal circumference and body weight with decreasing triglyceride level in patients with type 2 diabetes and metabolic syndrome | Request PDF

Request PDF | Telmisartan reduced abdominal circumference and body weight with decreasing triglyceride level in patients with type 2 diabetes and metabolic syndrome | Telmisartan has the dual ability to inhibit angiotensin II type 1 receptors and activate peroxisome proliferator-activated...

www.researchgate.net

Kidney health:

Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials - PubMed

We found that, based on a meta-analysis of 20 randomized controlled trials including >25,000 patients, telmisartan therapy is likely effective in the improvement of proteinuria/albuminuria or in the prevention of progression in proteinuria/albuminuria.

pubmed.ncbi.nlm.nih.gov

 

[Biobro]

Telmisartan is very overhyped in my opinion.
I used it couple years ago, for 6-months 80mg day. Its very mild, zero reduction in blood pressure, gained little bit fat, also caused joint/muscle pains. And despite it reduces visceral fat, it causes subq fat gain, so its trade off.
It also depletes ubiquinol levels, and inhibits nitric oxide production.

Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser1179 Dephosphorylation - PubMed

We demonstrated that telmisartan inhibited NO production and vessel relaxation at least in part by PP2A-mediated eNOS-Ser¹¹⁷⁹ dephosphorylation in a peroxisome proliferator-activated receptor γ-independent manner. These results may provide a mechanism that explains the inconsistent...

pubmed.ncbi.nlm.nih.gov

I should note that one big positive one was, 80mg/d telmi improved my kidney markers pretty good.

 

[BigTex]

Thanks Biobro, I had also previously seen these studies. All of which I sent to my cardiologists. He was hesitant to put me on Telmisartan but I was very persistent about it. I was already taking 325mg of Losartan and he wanted to put me on 40mg of Telmisartan. The equivalency is 80mg. So I tried the 40mg for two days then went 80mg and it started working very quickly. For me, it is much better than Losartan or Benicar. I am going to guess its due to the much longer half-life.

 

[Biobro]

Thanks Biobro, I had also previously seen these studies. All of which I sent to my cardiologists. He was hesitant to put me on Telmisartan but I was very persistent about it. I was already taking 325mg of Losartan and he wanted to put me on 40mg of Telmisartan. The equivalency is 80mg. So I tried the 40mg for two days then went 80mg and it started working very quickly. For me, it is much better than Losartan or Benicar. I am going to guess its due to the much longer half-life.

325mg of losartan wtf man? Thats massive dosage and can easily put you to hyperkalemia, if its used without potassium removing diuretics.
Its usually used 100mg-150mg day as a max prescribed dosage. But yeah telmisartan and valsartan are best arb’s in my opinion. Im using valsartan+nebivolol combo myself. But maybe going to give telmisartan for a second change, because it lowers visceral fat more than valsartan and has more small amount of other benefits. And i dont really care that much, if it lowers eNOs, nitric oxide in humans, because i already using good NO-stack as a base. And same with small increase subq fat caused by telmi didnt bother me that much, because longevity, visceral fat reduction and health benefits are more important to me than body composition.

 

[BigTex]

Yea, use a diuretic with it. I am guessing with me that the Telmisartan worked best because of the 24 hour half life. Losartan was 4.5 hours and Benicar 13 hours.

 

[Biobro]

rat study, but good to keep in mind.

Bone mineral density is reduced by telmisartan in male spontaneously hypertensive rats - PubMed

Results showed that telmisartan negatively affected bones suggesting that caution should be taken in possible therapeutic applications for protecting bone health in hypertensive conditions. More studies are necessary to clarify the mechanisms through which telmisartan favors bone loss in this model.

pubmed.ncbi.nlm.nih.gov

 

[Biobro]

Thats one mechanism why telmisartan has neuroprotective effects, because it increases prolactin and lowers dopamine. This is totally turn off for me. Because i personally would rather increase dopamine and lower prolactin.

Dynamics of endocrine and metabolic changes among patients with coronary artery disease, type 2 diabetes mellitus and metabolic syndrome while treating with telmisartan | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)

iej.zaslavsky.com.ua

While treating with telmisartan, the level of prolactin in males of the experimental group increased significantly, whereas in the comparison group, it did not change dramatically. Therefore, a considerable increase of prolactin levels in males and females was observed in telmisartan treatment.

Conclusions. The use of telmisartan as a part of combined therapy facilitates the reduction of the cortisol level (p > 0.05) and leads to a significant rise in male and female prolactin levels (within the range of reference values).

https://www.researchgate.net/figure/Repair-mechanisms-of-MMP-9-inhibitors-prolactin-and-various-renin-angiotensin-system_fig2_355172230

Telmisartan reduces angiotensin II and thus lowers dopamine levels.
Prolactin down-regulates dopamine and also protects the blood-brain barrier from damage.

 

[GreenMachineX]

Thats one mechanism why telmisartan has neuroprotective effects, because it increases prolactin and lowers dopamine. This is totally turn off for me. Because i personally would rather increase dopamine and lower prolactin.

Dynamics of endocrine and metabolic changes among patients with coronary artery disease, type 2 diabetes mellitus and metabolic syndrome while treating with telmisartan | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)

iej.zaslavsky.com.ua

While treating with telmisartan, the level of prolactin in males of the experimental group increased significantly, whereas in the comparison group, it did not change dramatically. Therefore, a considerable increase of prolactin levels in males and females was observed in telmisartan treatment.

Conclusions. The use of telmisartan as a part of combined therapy facilitates the reduction of the cortisol level (p > 0.05) and leads to a significant rise in male and female prolactin levels (within the range of reference values).

https://www.researchgate.net/figure/Repair-mechanisms-of-MMP-9-inhibitors-prolactin-and-various-renin-angiotensin-system_fig2_355172230

Telmisartan reduces angiotensin II and thus lowers dopamine levels.
Prolactin down-regulates dopamine and also protects the blood-brain barrier from damage.

Does an increase in prolactin mess with sleep?

 

[Zooka15]

Thats one mechanism why telmisartan has neuroprotective effects, because it increases prolactin and lowers dopamine. This is totally turn off for me. Because i personally would rather increase dopamine and lower prolactin.

Dynamics of endocrine and metabolic changes among patients with coronary artery disease, type 2 diabetes mellitus and metabolic syndrome while treating with telmisartan | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)

iej.zaslavsky.com.ua

While treating with telmisartan, the level of prolactin in males of the experimental group increased significantly, whereas in the comparison group, it did not change dramatically. Therefore, a considerable increase of prolactin levels in males and females was observed in telmisartan treatment.

Conclusions. The use of telmisartan as a part of combined therapy facilitates the reduction of the cortisol level (p > 0.05) and leads to a significant rise in male and female prolactin levels (within the range of reference values).

https://www.researchgate.net/figure/Repair-mechanisms-of-MMP-9-inhibitors-prolactin-and-various-renin-angiotensin-system_fig2_355172230

Telmisartan reduces angiotensin II and thus lowers dopamine levels.
Prolactin down-regulates dopamine and also protects the blood-brain barrier from damage.

I was on Telmisartan for years before switching to Losartan and also irbesartan. I currently am back on Telmisartan 40MG daily (this was my old dosage as well). The prolactin blood test is a part of my normal blood work that I have done every 4months. Never has my prolactin been elevated from Telmisartan or any ARB.

 

[Zooka15]

Telmisartan is very overhyped in my opinion.
I used it couple years ago, for 6-months 80mg day. Its very mild, zero reduction in blood pressure, gained little bit fat, also caused joint/muscle pains. And despite it reduces visceral fat, it causes subq fat gain, so its trade off.
It also depletes ubiquinol levels, and inhibits nitric oxide production.

Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser1179 Dephosphorylation - PubMed

We demonstrated that telmisartan inhibited NO production and vessel relaxation at least in part by PP2A-mediated eNOS-Ser¹¹⁷⁹ dephosphorylation in a peroxisome proliferator-activated receptor γ-independent manner. These results may provide a mechanism that explains the inconsistent...

pubmed.ncbi.nlm.nih.gov

Think again........

Effects of angiotensin receptor blockers on endothelial nitric oxide release: the role of eNOS variants - PubMed

The ARBs differentially enhanced NO release in ECs in a manner influenced by eNOS single nucleotide polymorphisms. These findings provide new insights into the effects of ARBs on EC-dependent vasodilation and eNOS function.

pubmed.ncbi.nlm.nih.gov

 

[Biobro]

I was on Telmisartan for years before switching to Losartan and also irbesartan. I currently am back on Telmisartan 40MG daily (this was my old dosage as well). The prolactin blood test is a part of my normal blood work that I have done every 4months. Never has my prolactin been elevated from Telmisartan or any ARB.

Studies says otherwise, also everything is invidual. example , some guys can take high dose trt and get no side effects, some guys have side effects even 70-100mg/wk. Invidual man, invidual. I personally been now taken again 80mg telmi for months, but to be honest i was feeling 100 times better with valsartan. Also last time when i checked my prolactin it was in upper range, because of the telmisartan? Maybe maybe not. But with valsartan my prolactin runs low-normal.

 

[Biobro]

Think again........

Effects of angiotensin receptor blockers on endothelial nitric oxide release: the role of eNOS variants - PubMed

The ARBs differentially enhanced NO release in ECs in a manner influenced by eNOS single nucleotide polymorphisms. These findings provide new insights into the effects of ARBs on EC-dependent vasodilation and eNOS function.

pubmed.ncbi.nlm.nih.gov

I found that same study months ago.

 

[Zooka15]

I found that same study months ago.

Ok , but you tell everyone here it decreases NO, you also tell everyone here it increases prolactin….let see all these labs and studies with numbers

 

[Biobro]

Ok , but you tell everyone here it decreases NO, you also tell everyone here it increases prolactin….let see all these labs and studies with numbers

Wtf man. Just speculation based on studies. We all know that there are invidual response. Atleast you should know that.

 

[SteveCleves]

Some were really good, but the ones that were really bad freaked me out.

I always take drug reviews on those sites with a grain of salt...you have to keep in mind that many people reviewing drugs have so many comorbidities and are on so many drugs that its almost impossible to isolate which drug or which interaction is causing them issues.

 

[SteveCleves]

something else to consider regarding ARBs, especially those people who are supplementing their TRT with nandrolone.

Role of the renin-angiotensin system in the nandrolone-decanoate-induced attenuation of the Bezold-Jarisch reflex - PubMed

The androgen nandrolone decanoate (ND) is known to cause cardiovascular abnormalities, such as attenuation of the Bezold-Jarisch Reflex (BJR), cardiac hypertrophy, and elevation of mean arterial pressure (MAP). Futhermore, a relationship between androgens and the renin-angiotensin system (RAS)...

pubmed.ncbi.nlm.nih.gov